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KMT2E Antibody

  • 货号：
    CSB-PA818269LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, NIH/3T3 whole cell lysate, 293T whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate
      All lanes: KMT2E antibody at 3.1μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 205, 196, 69, 99, 186, 181, 201, 132 kDa
      Observed band size: 80 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KMT2E Polyclonal antibody
  • Uniprot No.：
    Q8IZD2
  • 基因名：
    KMT2E
  • 别名：
    HDCMC04P antibody; Histone lysine N methyltransferase MLL5 antibody; Histone-lysine N-methyltransferase MLL5 antibody; KMT2E antibody; Lysine N methyltransferase 2E antibody; Lysine N-methyltransferase 2E antibody; MGC70452 antibody; Mll5 antibody; MLL5_HUMAN antibody; Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog; Drosophila) antibody; Myeloid/lymphoid or mixed lineage leukemia 5 antibody; Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KMT2E Antibody (CSB-PA818269LA01HU)，的标记方式是Non-conjugated。对于KMT2E Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818269LB01HU KMT2E Antibody, HRP conjugated ELISA
    FITC CSB-PA818269LC01HU KMT2E Antibody, FITC conjugated
    Biotin CSB-PA818269LD01HU KMT2E Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells.; Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
  • 基因功能参考文献：
    1. three dimensional structure of MLL5 SET domain unveils the structural basis for its lack of methyltransferase activity PMID: 27812132
    2. MLL5 preserves spindle bipolarity through maintaining cytosolic PLK1 in a nonaggregated form. PMID: 27002166
    3. MLL5 interacts with OGT and USP7 to form a stable ternary complex. Upregulation of MLL5 expression was correlated with increased expression of OGT and USP7 in human primary cervical adenocarcinomas. PMID: 26678539
    4. Suggest a role for MLL5 and H3.3 in maintaining self-renewal hierarchies in adult glioblastomas. PMID: 26626085
    5. O-GlcNAcylation of MLL5beta at T440 residue is critical for MLL5 recruitment to the HPV16/18-long control region through its interaction with AP-1. PMID: 25670814
    6. Improved outcome is observed in decitabine-treated patients who express MLL5 at high levels. PMID: 24895338
    7. KMT2E expression retained association with poor acute promyelocytic leukaemia remission rate and shorter survival while the association with disease-free survival was of marginal significance. PMID: 24796963
    8. NMR solution structure of the MLL5 PHD domain PMID: 24130829
    9. these results indicate that the suppression of MLL genes, especially MLL2 and MLL5, take part in modulating breast carcinogenesis. PMID: 23754336
    10. MLL5 is a cellular ligand for the natural cytotoxicity receptor NKp44. PMID: 23958951
    11. findings provide first insights into the molecular basis for the recruitment, exclusion, and regulation of MLL5 at chromatin PMID: 23798402
    12. MLL5 can associate with HCF-1 and then be recruited to E2F1-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation. PMID: 23629655
    13. A new isoform, MLL5beta, truncated in exon 14, regulates E6 & E7 transcription in cervical carcinoma cells. Interaction of MLL5beta with the AP-1-binding site at the distal region of the HPV18 long control region activated E6/E7 transcription. PMID: 21908553
    14. High MLL5 expression levels are associated with a favorable outcome and may improve risk and treatment stratification in acute myeloid leukemia PMID: 21205756
    15. Phosphorylation of MLL5 may have an indispensable role in the mitotic progression in mixed lineage leukemia cells. PMID: 20439461
    16. MLL5 forms intranuclear protein complexes that may play an important role in chromatin remodeling and cellular growth suppression. PMID: 14718661
    17. These findings provide evidence that MLL5 might be an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. PMID: 18573682
    18. MLL5 protein has been classified into a distinct subfamily with SETD5, because its SET domain and domain architecture show high homology with SETD5 rather than the members in MLL subfamily (i.e. MLL, MLL2, MLL3 and MLL4) PMID: 18231586
    19. MLL5 is a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. PMID: 12101424

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  • 亚细胞定位：
    Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle.; [Isoform 3]: Nucleus, nucleoplasm. Nucleus speckle.; [Isoform NKp44L]: Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
  • 组织特异性：
    Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum. Isoform NKp44L: Not detected on circulating cells from healthy individuals, but
  • 数据库链接：

    HGNC: 18541

    OMIM: 608444

    KEGG: hsa:55904

    STRING: 9606.ENSP00000257745

    UniGene: Hs.592262