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KLHL2 Antibody

  • 货号：
    CSB-PA012421LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue
      All lanes: KLHL2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 66, 67, 57 kDa
      Observed band size: 66, 67 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA012421LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA012421LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KLHL2 Polyclonal antibody
  • Uniprot No.：
    O95198
  • 基因名：
    KLHL2
  • 别名：
    ABP KELCH antibody; Actin binding protein Mayven antibody; Actin-binding protein Mayven antibody; kelch antibody; kelch like 2 antibody; Kelch like 2, Mayven antibody; Kelch like family member 2 antibody; Kelch like protein 2 antibody; Kelch-like protein 2 antibody; KLHL2 antibody; KLHL2_HUMAN antibody; MAV antibody; MAYVEN antibody; OTTHUMP00000219997 antibody; OTTHUMP00000219998 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Kelch-like protein 2 protein (1-155AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KLHL2 Antibody (CSB-PA012421LA01HU)，的标记方式是Non-conjugated。对于KLHL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012421LB01HU KLHL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA012421LC01HU KLHL2 Antibody, FITC conjugated
    Biotin CSB-PA012421LD01HU KLHL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
  • 基因功能参考文献：
    1. Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1, WNK3 and WNK4 within HEK293T cells. PMID: 23838290
    2. Results suggest a novel E3 ubiquitin ligase function of KLHL2, with NPCD as a substrate. PMID: 21549840
    3. overexpression of Mayven may promote tumor growth through c-Jun and cyclin D1 PMID: 15735724
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol.
  • 组织特异性：
    Ubiquitous. Detected throughout the brain.
  • 数据库链接：

    HGNC: 6353

    OMIM: 605774

    KEGG: hsa:11275

    STRING: 9606.ENSP00000424198

    UniGene: Hs.388668