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KLF3 Antibody

  • 货号：
    CSB-PA012393DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012393DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012393DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA012393DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KLF3 Polyclonal antibody
  • Uniprot No.：
    P57682
  • 基因名：
    KLF3
  • 别名：
    Basic krueppel-like factor antibody; Basic Kruppel like factor antibody; BKLF3 antibody; CACCC box binding protein BKLF antibody; CACCC-box-binding protein BKLF antibody; Klf3 antibody; KLF3_HUMAN antibody; Krueppel-like factor 3 antibody; Kruppel like factor 3 (basic) antibody; MGC48279 antibody; TEF-2 antibody; TEF2 antibody; Transcript ch138 antibody; Zinc finger protein 741 antibody; ZNF741 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Krueppel-like factor 3 protein (1-240AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis.
  • 基因功能参考文献：
    1. Low KLF3 expression is associated with colorectal cancer. PMID: 28423541
    2. Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3, contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review) PMID: 25979369
    3. Klf-3 expression is downregulated in human metastatic sarcomas, and Klf-3 levels negatively correlate with miR-182 expression. PMID: 26314219
    4. A feedback loop consisting of microRNA 23a/27a and the beta-like globin suppressors KLF3 and SP1 regulates globin gene expression. PMID: 23918807
    5. B cell differentiation is significantly impaired in the bone marrow, spleen, and peritoneal cavity of Klf3 null mice; the defects are cell autonomous. PMID: 22003205
    6. Low KLF3 is associated with acute myeloid leukemia. PMID: 21470678
    7. KLF3 is an important regulator of several biological processes, including adipogenesis, erythropoiesis, and B cell development. (Review) PMID: 21360637
    8. The recruitment of CtBP and sumoylation are required for full repression by BKLF. PMID: 15684403

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 16516

    OMIM: 609392

    KEGG: hsa:51274

    STRING: 9606.ENSP00000261438

    UniGene: Hs.298658