KL Antibody

1. sKlotho is a biomarker of renal dysfunction and a potential treatment target for renoprotection in T2 diabetes mellitus. PMID: 29509906
2. Soluble klotho levels were inversely related to brain atrophy in alcoholic patients. PMID: 29846497
3. The tissue klotho protein expression was associated with a lower risk and progression of malignancies. Klotho may be a protective factor against malignancies risk/progression. PMID: 29775618
4. Serum Klotho may be a novel risk factor for atherosclerosis in maintenance hemodialysis patients PMID: 30064142
5. a single maximal aerobic exercise session of 20 min duration induced serum levels of klotho, particularly in women PMID: 27251899
6. Knockdown of klotho gene expression normalized IGF-1R and Wnt1 protein expressions and Akt phosphorylation in granulosa cells from patients with PCOS; it also blocked the effects of insulin on apoptosis and proliferation in granulosa cells. PMID: 28673204
7. Schizophrenia patients, KL-VS has a selective effect on memory, with heterozygotes in CD and CS clusters performing worse than non-carriers PMID: 28673754
8. The change in concentration of soluble alpha-klotho during the 1.5-years follow-up was an indicator of CKD progression. Renal damage associated with a reduction of alpha-klotho may involve the upregulation of plasma aldosterone. PMID: 29843135
9. Cord blood klotho levels were inversely correlated with leptin and insulin levels at birth PMID: 29648999
10. solubility-Klotho level was closely correlated with kidney function PMID: 29061648
11. To evaluate the role of klotho in the pathogenesis of systemic sclerosis, its serum concentration was measured in patients compared to healthy controls, and its association with cutaneous and visceral involvement was assessed. Spearman's test showed no significant association between klotho serum levels and systemic sclerosis activity, concerning either clinical, laboratory or instrumental findings. PMID: 29320841
12. Klotho may play an inhibiting role in lipopolysaccharide-induced inflammation injury by inhibiting NF-kappaB and Wnt signaling pathways in HK-2 cells. PMID: 29441993
13. High klotho expression is associated with renal fibrosis and podocyte injuries. PMID: 29590173
14. Although our study revealed higher serum ET-1 and lower serum alpha-Klotho levels in systemic sclerosis patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement. PMID: 28831601
15. The A allele of the G395A polymorphism of Klotho, which emerges the higher levels of phosphate, may be associated with the risk of mortality in Iranian patients receiving hemodialysis. PMID: 29190606
16. This study showed that A reduced blood alpha-Klotho level was correlated with grading of cerebral Deep White Matter Lesions and was accompanied by cognitive decline as an independent risk factor. PMID: 29154273
17. Klotho deficiency is not just a biomarker but a contributing factor to the development of acute kidney injury. PMID: 29550818
18. Forced expression of Klotho resulted in decline of activation of IGF-1R signaling, accompanied by decreased phosphorylation of its downstream targets, including AKT and ERK1/2. These data indicated that Klotho acts as a tumor suppressor via inhibiting IGF-1R signaling, thus suppressing the viability and promoting apoptosis in Tcell lymphoma. PMID: 28656297
19. serum levels increase following kidney transplantation, although changes are modest compared to more significant improvements in renal function and iFGF-23 levels PMID: 28120476
20. The functional KL-VS variant of the KLOTHO gene protects against the development of retinopathy in patients with T1 diabetes. PMID: 29247834
21. the immunohistochemical expressions of Klotho and DNMT3a in tissues obtained from oral dysplasia and oral squamous cell carcinoma, is reported. PMID: 28303350
22. Klotho suppresses Sox9 upregulation and intranuclear translocation. Klotho inhibits high phosphate-induced osteogenic activity in human aortic valve interstitial cells. PMID: 28332126
23. Data suggest that serum levels of alpha-klotho and beta-klotho are down-regulated in patients with type 2 diabetes, regardless of diabetic complications. PMID: 27916483
24. Low expression levels of Klotho were observed in DLBCL patients and cell lines. Enforced expression of Klotho could significantly induce cell apoptosis and inhibit tumor growth in DLBCL. Upregulation of Klotho resulted in declined activation of IGF-1R signaling, accompanied with decreased phosphorylation of its downstream targets, including AKT and ERK1/2. PMID: 28153033
25. Data suggest that plasma alpha-klotho is down-regulated in subjects with type 2 diabetes as diabetic nephropathy progresses; plasma alpha-klotho level (not urinary alpha-klotho level) may be an early biomarker for predicting renal impairment in type 2 diabetes. PMID: 27037042
26. Hmgb1 can inhibit Klotho gene expression and malignant phenotype in melanoma cells through activation of NF-kappaB signaling. PMID: 27779100
27. patients with autosomal dominant polycystic kidney disease may potentially have different soluble alpha-Klotho production/clearance characteristics than the patients with other parenchymal renal diseases. PMID: 27733443
28. KL and SFRP1 methylation were more predominant in nasopharyngeal tumors. PMID: 28812223
29. The beta-Klotho gene expresses only in retina and optic nerve. The gamma-Klotho gene may regulate human lens epithelial cells' function mainly by the MAPK/ERK1/2 signaling pathway. PMID: 28095050
30. Down-Regulation of Soluble alpha-Klotho is Associated with Reduction in Serum Irisin Levels in Chronic Obstructive Pulmonary Disease. soluble a-klotho is one possible factor involved in reduced irisin release from skeletal muscle PMID: 27140192
31. Klotho is a co-receptor for FGF23. Together they play an important role in bone mineral and vitamin D metabolism. In chronic kidney disease, disturbances in bone metabolism increase cardiovascular risk. In the kidney, klotho induces phosphaturia. Klotho levels drop in chronic kidney disease. It inhibits vascular calcification. Review. PMID: 27118192
32. A single copy of klotho allele KL-VS is associated with longevity, better health, increased cognition, and bigger regional brain volume. PMID: 28431289
33. Review of Klotho function and dysfunction in mice and humans. [Review Article] PMID: 27576165
34. The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for homozygosis). PMID: 28539162
35. Our findings provide the first evidence that alpha-Klotho is significantly decreased in the microvasculature in systemic sclerosis skin PMID: 28183357
36. indicates an inverse interrelationship between inflammation and Klotho in atherosclerosis PMID: 28963437
37. Administration of soluble klotho significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis. PMID: 27979597
38. The role of Klotho protein in aging and central nervous system pathology is reviewed. PMID: 28988528
39. These results support the notion that sialogangliosides and lipid rafts are membrane receptors for sKlotho and that the KL1 domain is sufficient for the tested biologic activities. PMID: 28442546
40. Klotho is expressed in human dermal fibroblasts and dermal microvascular endothelial cells and is implicated in the process of angiogenesis. PMID: 27260080
41. A factor for functioning of the brain in aged is KLOTHO gene. PMID: 26405063
42. Data suggest Klotho attenuates ox-LDL- (oxidized low density lipoprotein)-induced oxidative stress in vascular endothelial cells via up-regulation of oxidative scavengers (lipoprotein and nitric oxide), activation of the PI3K/Akt/eNOS signaling, and down-regulation of LOX1 (lectin-like ox-LDL receptor) expression. (PI3K = phosphatidylinositol 3-Kinase; Akt = proto-oncogene c-Akt; eNOS = endothelial nitric oxide synthase) PMID: 28407763
43. Targeting klotho may thus represent a therapeutic strategy . PMID: 27696667
44. FGF23 affected NO synthesis and oxidative stress in human coronary artery endothelial cells are modulated by Klotho. PMID: 27448998
45. Conversely, siRNA-mediated Klotho silencing up-regulated Egr-1, FN, and Col I expression and the p-Smad3/Smad3 ratio. Moreover, the effects of si-Klotho on Egr-1 expression were abolished by the TGF-beta1 inhibitor SB-431542. Klotho overexpression can prevent mesangial ECM production in high-glucose-treated human MCs, an effect that has been partially attributed to Egr-1 down-regulation facilitated by TGF-beta1/Smad3 s... PMID: 28411025
46. Klotho levels were higher in acute kidney injury patients and females and lower in end stage renal disease patients than in healthy adults and patients with moderate chronic kidney disease. PMID: 28157067
47. Genetic polymorphisms such as the G-395A polymorphism in the promoter region of the Klotho gene have been associated with the development of essential hypertension. PMID: 27215557
48. Klotho was demonstrated to act as a potent tumor suppressor in human ovarian cancer cells. Reduced Klotho expression was detected in the specimens of patients with ovarian cancer, and overexpression of Klotho significantly inhibited cell proliferation of human ovarian cancer cells. PMID: 28259911
49. sKlotho is increased in active acromegaly and normalises after successful treatment. PMID: 27387242
50. Any polymorphism altering the function of klotho gene may result with stone formation. We found that there are more GG sequences of G395A gene in patients with urinary tract stone disease. That may be a polymorphism of klotho gene which results with stone formation. PMID: 26597587

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HGNC: 6344

OMIM: 211900

KEGG: hsa:9365

STRING: 9606.ENSP00000369442

UniGene: Hs.524953