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KIRREL2 Antibody

  • 货号：
    CSB-PA754407LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: KIRREL2 antibody at 8µg/ml
      Lane 1: Mouse gonadal tissue
      Lane 2: Mouse lung tissue
      Lane 3: Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 76, 68, 62, 24 kDa
      Observed band size: 76 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIRREL2 Polyclonal antibody
  • Uniprot No.：
    Q6UWL6
  • 基因名：
    KIRREL2
  • 别名：
    FILTRIN antibody; Kin of IRRE like 2 (Drosophila) antibody; Kin of IRRE-like protein 2 antibody; Kin of irregular chiasm like 2 antibody; Kin of irregular chiasm-like protein 2 antibody; KIRR2_HUMAN antibody; KIRREL2 antibody; NEPH3 antibody; Nephrin like 3 antibody; nephrin-like gene 1 antibody; Nephrin-like protein 3 antibody; NLG1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Kin of IRRE-like protein 2 protein (21-219AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIRREL2 Antibody (CSB-PA754407LA01HU)，的标记方式是Non-conjugated。对于KIRREL2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA754407LB01HU KIRREL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA754407LC01HU KIRREL2 Antibody, FITC conjugated
    Biotin CSB-PA754407LD01HU KIRREL2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate basal insulin secretion.
  • 基因功能参考文献：
    1. SNP V353M confers high risk of renal failure in primary hematuric glomerulopathies and predisposition to microalbuminuria in the general population PMID: 28334007
    2. summarize the current knowledge of the functions of nephrin and Neph-family proteins and transcription factors and agents that control nephrin and Neph3 gene expression. PMID: 24219158
    3. Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-kappaB and silenced by DNA methylation. PMID: 21980157
    4. Identification of Filtrin as a member of nephrin-like proteins. PMID: 12504092
    5. KIRREL2 protein is a beta-cell-expressed Ig domain protein and may be involved in pancreas development or beta cell function PMID: 12837264
    6. Filtrin can act as autoantigen, and autoantibodies against these can be detected in patients with type 1 diabetes. PMID: 16741999
    7. NF-kappaB and Sp1 response elements are essential for the basal transcriptional activity of the Neph3 promoter. PMID: 19703278
    8. Filtrin is a novel protein with substantial homology to nephrin. It is a transmembrane protein of the immunoglobulin superfamily (apparent molecular weight 107 kDa) and most prominently expressed in the pancreas, lymph nodes as well as kidney glomerulus. PMID: 12504092

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Highly expressed in beta-cells of the pancreatic islets.
  • 数据库链接：

    HGNC: 18816

    OMIM: 607762

    KEGG: hsa:84063

    STRING: 9606.ENSP00000353331

    UniGene: Hs.145729