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KIR3DS1 Antibody

  • 货号：
    CSB-PA614817LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA614817LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIR3DS1 Polyclonal antibody
  • Uniprot No.：
    Q14943
  • 基因名：
    KIR3DS1
  • 别名：
    KIR3DS1 antibody; NKAT10Killer cell immunoglobulin-like receptor 3DS1 antibody; MHC class I NK cell receptor antibody; Natural killer-associated transcript 10 antibody; NKAT-10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Killer cell immunoglobulin-like receptor 3DS1 protein (198-335AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIR3DS1 Antibody (CSB-PA614817LA01HU)，的标记方式是Non-conjugated。对于KIR3DS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA614817LB01HU KIR3DS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA614817LC01HU KIR3DS1 Antibody, FITC conjugated
    Biotin CSB-PA614817LD01HU KIR3DS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor on natural killer (NK) cells for MHC class I molecules. Upon interaction with peptide-free HLA-F open conformer, triggers NK cell degranulation and anti-viral cytokine production.
  • 基因功能参考文献：
    1. interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. PMID: 30031767
    2. The combination of KIR3DS1 with homozygosity for HLA-Bw4 alleles (the putative ligand for KIR3DS1) was significantly less frequent in the HIV-1 infected group than in the control group PMID: 29664957
    3. Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups. PMID: 29032460
    4. KIR3DS1*01301, 3DL1*00401, and 3DL1*00402 showed susceptibility and elevated mRNA expression and is associated with antibody mediated acute rejection and chronic rejection. PMID: 28942035
    5. Study assessed which of the TB01 encoded KIR gene products contributed to Natural Killer cell responsiveness; of the TB01 KIR gene products examined, only KIR3DS1 conferred responsiveness to HLA-null stimulation, demonstrating its ligation can activate ex vivo Natural Killer cells. PMID: 28938026
    6. genetic polymorphism is not related to acute myeloid leukemia in Chinese population PMID: 25636577
    7. The data from this study contribute novel insight into how KIR3DS1-specific polymorphisms in the extracellular region impact KIR3DL1 surface expression, ligand binding, and inhibitory function. PMID: 26109640
    8. Data suggest that low level of activating KIR3DS1 and its combination with HLA-B Bw4Ile80 ligand might have an influence on the susceptibility to tuberculosis (TB) in Lur population of Iran. PMID: 22426166
    9. KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of ankylosing spondylitis in the Chinese population. PMID: 22744805
    10. Results show that the KIR3DS1 genotype has a positive effect on HCV viral clearance during the first weeks of Peg-IFN/RBV treatment in HCV/HCV co-infected patients bearing genotype 1, and higher RVR and SVR rates. PMID: 23613999
    11. results suggest that the sole presence of KIR3DS1 could have a protective role in HIV-1 infection in highly exposed and persistently seronegative individuals PMID: 23789883
    12. There is evidence of the association of activating KIR genotypes with an increased risk for autoimmune disease PMID: 21779711
    13. Our results that KIR2DL5 and KIR3DS1 may have a predisposing role in multiple sclerosis PMID: 21665278
    14. These data provide the first evidence for the direct binding of KIR3DS1(+) cells to HLA-Bw4 and highlight the key role for position 138 in determining ligand specificity of KIR3DS1 PMID: 21804024
    15. The most significant difference in PFS observed in multiple myeloma patients after autologous stem cell transplantation was with those with GR KIR3DS1(+) in whom HLA-Bw4, the ligand for the corresponding inhibitory receptor KIR3DL1, was missing PMID: 20562327
    16. The increased frequency of the KIR3DS1*013 allele in patients with amnkylosing spondylitis is clearly independent of the presence of the HLA-Bw4I80 epitope. PMID: 20131260
    17. Compared with KIR3DS1(-) donors, donor KIR3DS1 was associated with lower-grade II-IV acute graft-versus-host disease. PMID: 20124216
    18. Carriage of activating 3ds1 was increased in patients with herpes virus RDs. PMID: 17592337
    19. Sequencing analysis identified a variant with a complex deletion/substitution mutation in exon 4 (which encodes the D1 extracellular domain), resulting in a premature stop codon and might affect its expression and activating capacity PMID: 17687550
    20. Variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication. PMID: 18025129
    21. We observed that possessing KIR3DS1 was associated with higher NK cell effector functions in early HIV-1 disease, despite the absence of HLA Bw4Ile80, a putative ligand of KIR3DS1. PMID: 18305035
    22. KIR3DS1 expression on NK cells can be induced after exposure to stimulator cells PMID: 19454667

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed in NK and T-cell lines but not in B-lymphoblastoid cell lines or in a colon carcinoma cell line.
  • 数据库链接：

    HGNC: 6340

    OMIM: 604946

    KEGG: hsa:3813

    STRING: 9606.ENSP00000375608

    UniGene: Hs.645228