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KIR2DS5 Antibody

  • 货号：
    CSB-PA619902LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA619902LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIR2DS5 Polyclonal antibody
  • Uniprot No.：
    Q14953
  • 基因名：
  • 别名：
    KIR2DS5 antibody; CD158G antibody; NKAT9Killer cell immunoglobulin-like receptor 2DS5 antibody; CD158 antigen-like family member G antibody; MHC class I NK cell receptor antibody; Natural killer-associated transcript 9 antibody; NKAT-9 antibody; CD antigen CD158g antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Killer cell immunoglobulin-like receptor 2DS5 protein (162-242AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIR2DS5 Antibody (CSB-PA619902LA01HU)，的标记方式是Non-conjugated。对于KIR2DS5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA619902LB01HU KIR2DS5 Antibody, HRP conjugated ELISA
    FITC CSB-PA619902LC01HU KIR2DS5 Antibody, FITC conjugated
    Biotin CSB-PA619902LD01HU KIR2DS5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry.
  • 基因功能参考文献：
    1. KIR2DS5 gene may be protective against hypertension. PMID: 29105364
    2. The presence ofKIR2DS5 reduced the risk of endometriosis if a female possessed alleles from group C2 of HLA-C. PMID: 25724317
    3. The presence of KIR2DS2/2DL2 with KIR2DS5 abrogated the risk of KIR2DS2/2DL2 and the protective benefit of KIR2DS5. PMID: 24571473
    4. genetic polymorphism impacts glycosylation and protein expression level PMID: 24269691
    5. The activating KIR2DS5 gene was significantly increased in thyroid ancer patients compared to the controls. PMID: 22836040
    6. Data indicate that killer-cell immunoglobulin-like receptors (KIRs)activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes are associated with severe pandemic influenza A (H1N1) 2009 infections. PMID: 22652695
    7. In summary, KIR polymorphisms may be involved in the development of Epstein-Barr virus associated hemophagocytic lymphohistiocytosis, with KIR2DS5 promoting susceptibility to this disease. PMID: 22376216
    8. increase in the allele distribution in northern province of Tehran compared with that reported for the southern Iran population PMID: 21867738
    9. predisposition to systemic lupus erythematosus was associated with GTGT deletion at the SLC11A1 3'UTR, presence of KIR2DS2 +/KIR2DS5 +/KIR3DS1 + profile, increased number of stimulatory KIR genes and European and Amerindian ancestries PMID: 21233146
    10. The presence of KIR2DS5 gene protects human from endometriosis, ankylosing spondylitis, and acute rejection of kidney graft. PMID: 20865034
    11. reduced allele frequency in African Americans PMID: 19410616
    12. Donor activating KIR2DS5 may improve disease-free survival in non T-cell-depleted haploidentical hematopoietic stem cell transplantation. PMID: 18315912
    13. Positive linkage disequilibrium was seen and between KIR3DS1 and KIR2DS5. PMID: 12559621
    14. Carriage of activating 2ds5 was increased in patient with herpes virus RDs. PMID: 17592337
    15. The most frequent allele found in 132 cell lines from International Workshop samples is KIR2DS5*005, an allele characteristic of African populations. PMID: 18498296
    16. The stimulatory KIR2DS5 gene was associated with improved leukemia free survival. PMID: 18555529
    17. KIR2DS5 gene codes for a surface receptor triggering natural killer cell function. PMID: 18624290
    18. The level of KIR2DS5 surface expression was impacted by residue 47 but that variation at several residues in the D2 domain of KIR2DS5 ultimately had a more profound effect. PMID: 18682925
    19. Lack of activation KIR2DS5 may play an important role in the development of bronchiolitis obliterans but not in the control of cytomegalovirus reactivation after lung transplantation. PMID: 18765192
    20. KIR2DS1 incompatibilities increased risk of relapse after allogeneic hematopoietic stem cell transplantation PMID: 19500138

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein; Extracellular side.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Expressed on a discrete subset of peripheral blood NK cells.
  • 数据库链接：

    HGNC: 6337

    OMIM: 604956

    KEGG: hsa:3810

    UniGene: Hs.744266