KIFC1 Antibody
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货号:CSB-PA012348GA01HU
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规格:¥3,900
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其他:
产品详情
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Uniprot No.:Q9BW19
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基因名:KIFC1
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别名:HSET antibody; HSET KNSL2 antibody; KIF C1 antibody; KIFC 1 antibody; KIFC1 antibody; KIFC1_HUMAN antibody; Kinesin family member C1 antibody; Kinesin like 2 antibody; Kinesin like protein 2 antibody; Kinesin like protein KIFC1 antibody; Kinesin related protein HSET antibody; Kinesin-like protein 2 antibody; Kinesin-like protein KIFC1 antibody; Kinesin-related protein HSET antibody; KNSL 2 antibody; KNSL2 antibody; MGC1202 antibody; MGC149736 antibody; MGC149737 antibody; Mitotic kinesin like protein 2 antibody; MKLP 2 antibody; MKLP2 antibody; RAB6 KIFL antibody; Rabkinesin 6 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Human KIFC1
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免疫原种属:Homo sapiens (Human)
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抗体亚型:IgG
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纯化方式:Antigen Affinity purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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产品提供形式:Liquid
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应用范围:ELISA,WB,IF
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Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure.
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基因功能参考文献:
- Data show that kinesin-related protein HSET (HSET) is incapable of forming asters from preformed, nongrowing microtubule (non-MT) MTs, but rapidly forms MT asters in the presence of soluble (non-MT) tubulin. PMID: 29985404
- KIFC1 interacts with F508del-CFTR. PMID: 30066085
- nuclear KIFC1 (nKIFC1) correlated significantly with Ki67 in White triple-negative breast cancer (TNBCs) but not in African American (AA) TNBCs, suggesting that nKIFC1 is not merely a surrogate for proliferation in AA TNBCs. PMID: 28218233
- Results identified Stathmin as a direct target of KIFC1. PMID: 28885720
- The overexpression of KIFC1 was correlated closely with the progression of hepatocellular carcinoma (HCC) and poor prognosis, and suggested that the expression levels of KIFC1 are a potential prognostic biomarker for HCC. PMID: 29620256
- Circulating pri-miRNA-944 and 3662 can improve non-invasive potential non-small cell lung cancer detection of operable stages of SCC and AC PMID: 28964573
- These findings reveal a new stationary binding model that kinesin-14 KIFC1 proteins function as crosslinkers between the Golgi apparatus and the microtubules and contribute to the central positioning and structural maintenance of the Golgi apparatus. PMID: 28430595
- Taken together, these results suggest that up-regulation of KIFC1 may induce docetaxel resistance. PMID: 27665358
- Low post translational modifications of KIFC1 protein is associated with neoplasms. PMID: 28209915
- KIFC1 is overexpressed in GC. PMID: 27176706
- Association of KIFC1 gene expression and centrosome amplification with high-grade serous ovarian carcinoma. PMID: 26992853
- stabilization of the centrosome-spindle pole interface by the CEP215-HSET complex could promote survival of cancer cells containing supernumerary centrosomes. PMID: 26987684
- KIFC1 silencing significantly reduces breast cancer cell viability. PMID: 26177331
- Data provides the first evidence of centrosome clustering-independent activities of HSET that fuel tumor progression. PMID: 25788277
- We show that some are new substrates of the anaphase-promoting complex/cyclosome and validate KIFC1 and RacGAP1/Cyk4 as two such targets involved respectively in timely mitotic spindle disassembly and cell spreading PMID: 24857844
- Our data underscore KIFC1 as a putative biomarker that predicts worse prognosis, poor overall survival and may serve as a potential marker of onset of metastatic dissemination in ovarian cancer patients. PMID: 25028599
- Study demonstrates microtubule tip-tracking of human kinesin-14 HSET and show that EB1 is sufficient to induce this dynamic microtubule end localization. PMID: 24039245
- Acentrosomal spindle assembly mechanisms are hyperactive in cancer cells and promote HSET. PMID: 22946058
- we suggest that KIFC1 plays an essential role for bipolar MTOC formation and maintaining chromosomal stability in the mitosis . PMID: 23318213
- A case-control analysis was carried out by comparing the genotype distribution of six KIFC1 single-nucleotide polymorphisms between 93 aspirin exacerbated respiratory disease cases and 96 aspirin-tolerant asthma controls in a Korean population PMID: 22201025
- The intense placental expression of KIFC1 in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 and KIF17 expression are increased of both in preeclamptia and diabetes. PMID: 19679349
- An analysis was made of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2. PMID: 17326138
- HSET has a role in controlling spindle length by cross-linking and sliding microtubules. PMID: 19116309
- High KIFC1 expression is associated with metastatic spread to the brain in primary non-small cell lung cancer. PMID: 19190132
- Chromosome congression in HSET + hNuf2 co-depleted cells required the plus-end directed motor CENP-E , which has been implicated in the gliding of mono-oriented kinetochores alongside adjacent K-fibres. PMID: 19525938
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亚细胞定位:Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Early endosome.
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蛋白家族:TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, NCD subfamily
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数据库链接:
HGNC: 6389
OMIM: 603763
KEGG: hsa:3833
STRING: 9606.ENSP00000393963
UniGene: Hs.436912
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