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KIF13B Antibody

  • 货号：
    CSB-PA873625LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA873625LA01HU diluted at 1:400 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system.
    • Immunofluorescence staining of A549 cells with CSB-PA873625LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIF13B Polyclonal antibody
  • Uniprot No.：
    Q9NQT8
  • 基因名：
    KIF13B
  • 别名：
    GAKIN antibody; Guanylate kinase associated kinesin antibody; KI13B_HUMAN antibody; KIAA0639 antibody; KIF 13B antibody; KIF13B antibody; Kinesin 13B antibody; Kinesin family member 13B antibody; Kinesin like protein GAKIN antibody; Kinesin like protein KIF13B antibody; Kinesin-like protein GAKIN antibody; Kinesin-like protein KIF13B antibody; OTTHUMP00000225649 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kinesin-like protein KIF13B protein (1531-1701AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIF13B Antibody (CSB-PA873625LA01HU)，的标记方式是Non-conjugated。对于KIF13B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873625LB01HU KIF13B Antibody, HRP conjugated ELISA
    FITC CSB-PA873625LC01HU KIF13B Antibody, FITC conjugated
    Biotin CSB-PA873625LD01HU KIF13B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.
  • 基因功能参考文献：
    1. Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression. PMID: 28134340
    2. Findings show that the high-affinity binding of KIF13B to DLG guanylate kinase (GK) domain does not require phosphorylation of KIF13B and that DLG binds to an unphosphorylated and autonomously folded domain within its stalk region (MAGUK binding stalk [MBS] domain) with high specificity and affinity. PMID: 27642159
    3. lnc-KIF13B-1, a long non-coding RNA (rs6434720) is associated with corticobasal degeneration. PMID: 26077951
    4. KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis. PMID: 25128562
    5. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. PMID: 21057110
    6. These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation. PMID: 20194617
    7. These results suggest that, in neurons, the GAKIN-PIP3BP complex transports PIP3 to the neurite ends and regulates neuronal polarity formation. PMID: 16864656
    8. Binding of the SH3-I3-GUK module of hDlg to GAKIN activates the microtubule-stimulated ATPase activity of GAKIN by approximately 10-fold. We propose: the cargo-mediated regulation of motor activity is a general paradigm for the activation of kinesins. PMID: 17696365

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, axon. Note=accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 14405

    OMIM: 607350

    KEGG: hsa:23303

    STRING: 9606.ENSP00000427900

    UniGene: Hs.444767