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KIF13A Antibody

  • 货号：
    CSB-PA880944LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA880944LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA880944LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KIF13A Polyclonal antibody
  • Uniprot No.：
    Q9H1H9
  • 基因名：
    KIF13A
  • 别名：
    bA500C11.2 antibody; FLJ27232 antibody; Homolog of mouse KIF13A mannose 6 phosphate receptor transporter antibody; KI13A_HUMAN antibody; KIF 13A antibody; Kif13a antibody; Kinesin family member 13A antibody; Kinesin like protein KIF13A antibody; Kinesin like protein RBKIN antibody; Kinesin-like protein KIF13A antibody; Kinesin-like protein RBKIN antibody; RBKIN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Kinesin-like protein KIF13A protein (1383-1537AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KIF13A Antibody (CSB-PA880944LA01HU)，的标记方式是Non-conjugated。对于KIF13A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA880944LB01HU KIF13A Antibody, HRP conjugated ELISA
    FITC CSB-PA880944LC01HU KIF13A Antibody, FITC conjugated
    Biotin CSB-PA880944LD01HU KIF13A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
  • 基因功能参考文献：
    1. the crystal structure of a catalytically active kinesin-13 monomer (Kif2A) in complex with two bent alphabeta-tubulin heterodimers in a head-to-tail array, providing a view of these interactions, is reported. PMID: 29980677
    2. that KIF13A plays an important role in the transport of influenza A viral ribonucleoproteins PMID: 29061883
    3. KIF13A interacts and cooperates with RAB11 to generate endosomal tubules. PMID: 24462287
    4. kjh kiiou ouiy 8yt 8iy 7i9y PMID: 24859087
    5. the kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization PMID: 21873978
    6. Functionally characterizes the homologous mouse protein. PMID: 11106728
    7. PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A. PMID: 20208530
    8. show that the clathrin adaptor AP-1 and the kinesin motor KIF13A together create peripheral recycling endosomal subdomains in melanocytes required for cargo delivery to maturing melanosomes. PMID: 19841138

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Endosome membrane. Golgi apparatus membrane. Note=Recruited to the midbody during cytokinesis.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 组织特异性：
    Widely expressed, with highest levels in heart, brain and skeletal muscle.
  • 数据库链接：

    HGNC: 14566

    OMIM: 605433

    KEGG: hsa:63971

    STRING: 9606.ENSP00000259711

    UniGene: Hs.94499