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  4. KIDINS220 Antibody

KIDINS220 Antibody

  • 货号：
    CSB-PA012306GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9ULH0
  • 基因名：
  • 别名：
    Ankyrin repeat-rich membrane-spanning protein antibody; arms antibody; KDIS_HUMAN antibody; kidins220 antibody; Kinase D interacting substance of 220 kDa antibody; Kinase D-interacting substrate of 220 kDa antibody; rgd 619949 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KIDINS220
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • 基因功能参考文献：
    1. Kidins220 has a prominent role in tumor development by participating in a complex signaling pathways. (Review) PMID: 28849114
    2. The Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. PMID: 27858709
    3. s hence propose that the identified homozygous loss-of-function variant in KIDINS220 causes the phenotype in the presented fetuses, and that this represents a hitherto undescribed severe autosomal recessive neurodevelopmental disorder. PMID: 28934391
    4. This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease. PMID: 27005418
    5. the existence of novel Kidins220/ARMS splice isoforms with unique properties PMID: 26083449
    6. Our results establish the role of ARMS in microglial activation by HIV Tat PMID: 25636783
    7. Kidins220 is expressed in neuroblastoma tumors and stabilizes NGF-induced, but not BDNF-induced, survival signaling in neuroblastoma cell lines. PMID: 23999075
    8. Kidins220 levels are increased in human brain necropsies from Alzheimer's disease patients. Kidins220 localizes within hyperphosphorylated tau aggregates, and is a substrate for GSK3beta. PMID: 23118350
    9. Kidins220 depletion is associated with the neural-to Schwann-like transition in neuroblastoma. PMID: 23333500
    10. Kidins220 is a novel T-cell receptor (TCR)-interacting protein that couples B-Raf to the TCR. Kidins220 is mandatory for sustained Erk signaling and is crucial for TCR-mediated T cell activation. PMID: 23359496
    11. Kidins220/ARMS is a functional mediator of multiple receptor signalling pathways. PMID: 22562556
    12. a novel partner of Kidins220/ARMS PMID: 22609016
    13. induction of morphological polarization in primary T lymphocytes and Jurkat cells enhances Kidins220/ARMS colocalization with ICAM-3 PMID: 21381019
    14. Ankyrin repeat-rich membrane spanning expression, conjunctly with tumour thickness or ulceration, may serve as a prognostic factor in patients with cutaneous melanoma. PMID: 21343931
    15. endogenous PKD1, PKD2, and Kidins220 co-exist with neurotensin-containing vesicles PMID: 18048355
    16. Down-regulation of ARMS results in inhibition of anchorage-independent growth in soft agar and restrictive growth of melanoma in severe combined immunodeficient mice PMID: 18089783
    17. Ankyrin-rich membrane spanning protein is a major factor that links neurotrophin signaling to nuclear factor-kappa B. PMID: 18501627
    18. sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593

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  • 相关疾病：
    Spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Late endosome. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
  • 组织特异性：
    Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • 数据库链接：

    HGNC: 29508

    OMIM: 615759

    KEGG: hsa:57498

    STRING: 9606.ENSP00000256707

    UniGene: Hs.467627