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KIAA0391 Antibody

  • 货号：
    CSB-PA012187GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O15091
  • 基因名：
    KIAA0391
  • 别名：
    Kiaa0391 antibody; KIAA0391 gene antibody; Mitochondrial ribonuclease P protein 3 antibody; Mitochondrial RNase P protein 3 antibody; Mitochondrial RNase P subunit 3 antibody; MRPP3 antibody; MRRP3_HUMAN antibody; PRORP antibody; Proteinaceous RNase P antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KIAA0391
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.
  • 基因功能参考文献：
    1. This study presents the crystal structure of human MRPP3, which features a remarkably distorted and hence non-productive active site that s propose will switch to a fully productive state only upon association with MRPP1, MRPP2 and pre-tRNA substrate. PMID: 25953853
    2. using a genome-wide association study, found that posttranscriptional modification of functionally important sites in mitochondrial transfer RNAs (tRNAs) is under strong genetic control, largely driven by a missense mutation in MRPP3 PMID: 24763589
    3. Inhibition of mitochondrial RNase P by beta-amyloid is an unspecific effect and is not mediated by beta-amyloid interaction with SDR5C1. PMID: 23755257
    4. Haplotypes in KIAA0391 and PSMA6 genes is a genetic link for myocardial infarction and coronary artery disease. PMID: 19624571
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    PPR family, P subfamily
  • 数据库链接：

    HGNC: 19958

    OMIM: 609947

    KEGG: hsa:9692

    STRING: 9606.ENSP00000454657

    UniGene: Hs.458487