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KDM5B Antibody

  • 货号：
    CSB-PA176057
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA176057(KDM5B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UGL1
  • 基因名：
    KDM5B
  • 别名：
    Cancer/testis antigen 31 antibody; CT31 antibody; Histone demethylase JARID1B antibody; JARID1B antibody; Jumonji AT rich interactive domain 1B antibody; Jumonji/ARID domain-containing protein 1B antibody; Kdm5b antibody; KDM5B_HUMAN antibody; Lysine (K) specific demethylase 5B antibody; Lysine demethylase 5B antibody; Lysine specific demethylase 5B antibody; Lysine-specific demethylase 5B antibody; PLU-1 antibody; PLU1 antibody; PPP1R98 antibody; Protein phosphatase 1 regulatory subunit 98 antibody; PUT1 antibody; putative DNA/chromatin binding motif antibody; RBBP2H1A antibody; RBP2 like antibody; RBP2-H1 antibody; Retinoblastoma-binding protein 2 homolog 1 antibody; Retinoblastoma-binding protein 2 homolog 1A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human KDM5B
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
  • 基因功能参考文献：
    1. Data reinforces the recent observation that the KDM5B haploinsufficiency is not a mechanism involved in intellectual disability and that KDM5B disorder associated with loss of heterozygosity variants is a recessive disorder. PMID: 30217758
    2. Altered splicing of JARID1B may be important factor increasing melanoma aggressiveness. PMID: 29246117
    3. both KDM5A and KDM5B are involved in the lengthening of DICER1 PMID: 28138513
    4. HBx activates the histone demethylase KDM5B and induces hepatic progenitor cell-like features in hepatocellular carcinoma PMID: 28566884
    5. JARID1B directly bound to PI3K/AKT signaling inhibitor SHIP1 gene promoter and decreased SHIP1 gene expression. PMID: 27584795
    6. We established the function of JARID1B in mediating the cancer stem cell potential of G0-like cells and our results expand understanding of its context-specific roles in malignant and normal stem cell homeostasis PMID: 27488530
    7. KDM5B is up-regulated in esophageal squamous cell carcinoma cells.MiR-194 targets KDM5B to inhibit esophageal squamous cell carcinoma development and progression. PMID: 27480251
    8. research suggests that miR424-5p may act as a novel anti-oncogene in cervical cancer by blocking cell growth through targeting KDM5B-Notch pathway PMID: 28082020
    9. JARID1B is involved in the pathogenesis of glioma. PMID: 27246838
    10. PLU-1 was overexpressed in colorectal cancer tissue compared with healthy colon. PLU-1 expression positively correlated with colorectal cancer progression. PMID: 27635108
    11. Hsa-miR-448 disrupting KDM5B-MALAT1 signalling axis and associated activities in TNBC cells, projects it as a putative therapeutic factor for selective eradication of TNBC cells. PMID: 26917489
    12. data indicate that parallel immunohistochemical assays of the expression levels of all the isoforms and of the RBP2-H1 variant of JARID1B may be an efficient technique of differentiating between benign naevi and melanomas PMID: 25789538
    13. KDM5B, a histone demethylase known to be involved in breast cancer tumorigenesis, as a target of miR-137. PMID: 26621457
    14. Data show that KDM5B is frequently up-regulated in hepatocellular carcinoma tissues and cell lines and correlated with poor prognosis. Its depletion leads to highly impaired clonogenesis and cell cycle arrest through up-regulation of p15 and p27. PMID: 26911146
    15. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. PMID: 26645689
    16. The data demonstrated that protein expression of p16 and JARID1B/KDM5B is negatively correlated in invasive ductal carcinoma of the breast. PMID: 26125737
    17. provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB PMID: 25951238
    18. Our results, for the first time, portray a pivotal role of JARID1B in stimulating metastatic behaviors of hepatocellular carcinoma cells PMID: 25909289
    19. Our results collectively suggested that JARID1B expressed in lung cancer played a role in lung cancer cells proliferation and invasion, which may be partly associated with the p53 expression PMID: 25877751
    20. PLU-1/JARID1B represents a candidate proliferation biomarker for HNSCC diagnosis and treatment. PMID: 25777981
    21. This study revealed hyper JARID1B expression and hypo histone H3 lysine 4 tri-methylation in mantle cell lymphoma PMID: 25755704
    22. Data show that double mutations on the residues in the interface (L325A/D328A) decreases the histone H3 H3K4me2/3 demethylation activity of lysine (K)-specific demethylase 5B (KDM5B). PMID: 24952722
    23. Silencing shJARID1B inhibits migration and invasion of human oral squamous cell carcinoma, reduces cancer stem cell activities and potentiates tumor-inhibiting radiotherapeutic effects. PMID: 26184998
    24. Study reports that KDM5B (PLU-1/JARID1B), a histone lysine demethylase of Jumonji family, associates with PRC2 and colocalizes with PRC2 in nuclear bodies, and their physical association is dependent on direct interaction between KDM5B and the SUZ12 component of PRC2. PMID: 24619877
    25. these results indicate that KDM5B represses Cx26 expression in the bladder cancer development. PMID: 23579952
    26. correlation between JARID1B level and chemotherapy resistance was observed in patients with epithelial ovarian cancer (odds ratio (OR) 36.81, 95% CI 4.84-280.11, P < 0.001). PMID: 25663457
    27. KDM5B promoted glioma proliferation partly via regulation of the expression of p21. PMID: 25450384
    28. Our results provide global and functional insight into the role of KDM5B in regulating H3K4 methylation marks near promoters, gene bodies, and enhancers in ES cells and during differentiation. PMID: 24495580
    29. Our findings suggest that Myc-mediated transcriptional repression of JARID1B counterintuitively inhibits Myc-regulated cell proliferation and potentially tumorigenesis. PMID: 24481781
    30. Integrated JARID1B chromatin binding, H3K4 methylation, and expression profiles suggest a key function for JARID1B in luminal cell-specific expression programs. PMID: 24937458
    31. KDM5B is SUMOylated at lysine residues 242 and 278 and that the ectopic expression of the hPC2 SUMO E3 ligase enhances this SUMOylation. PMID: 23970103
    32. The first and third, but not the second, PHD fingers of KDM5B possess histone binding activities. PMID: 24412361
    33. JARID1B and PHF2 are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression PMID: 22534467
    34. Our results suggest that KDM5B is a bona fide DNA damage response protein and indicate that KDM5B is an important genome caretaker and a critical regulator of genome stability. PMID: 24778210
    35. A novel role of KDM5B histone lysine demethylase in epithelial-mesenchymal transition, which may contribute to malignant progression of cancer. PMID: 23759590
    36. JARID1B plays a role in colorectal cancer maintenance. PMID: 23354547
    37. Contrary to earlier reports, this study shows enhanced expression of JARID1B by melanoma cells and indicates that such an enhancement may be an early event in the disease progression and is not correlated with melanoma invasiveness. PMID: 23262439
    38. analysis of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen PMID: 23408432
    39. This study demonstrates that JARID1B is expressed by uveal melanoma cells. PMID: 22669717
    40. Jarid1a/b-mediated H3K4 demethylation contributes to silencing of retinoblastoma target genes in senescent cells, suggesting a mechanism by which retinoblastoma triggers gene silencing. PMID: 22615382
    41. demonstrated that while TFAP2C and Myc can downregulate the CDKN1A promoter independently, KDM5B acts as a corepressor dependent on the other two proteins PMID: 22371483
    42. By displacing histone H3K4 demethylase PLU-1, FOXP3 increases both H4K16 acetylation and H3K4 trimethylation at the FOXP3-associated chromatins of multiple FOXP3-activated genes. PMID: 22152480
    43. JARID1B demethylase contributes to tumor cell proliferation through the epigenetic repression of a tumor suppressor miR PMID: 21969366
    44. JARID1B & LSD1 act in a sequential, coordinated manner to demethylate H3K4. JARID1B represses CCL14 expression, suppressing the angiogenic and metastatic potential of breast cancer cells in vivo. PMID: 21937684
    45. crystal of JARID1B belonged to space group P4(3), with unit-cell parameters a = 51.7, b = 51.7, c = 36.2 A PMID: 21821892
    46. JARID1B is widely expressed in estrogen receptor+ breast cancers and breast cancer cell lines PMID: 21369698
    47. there is a significant increase in the percentage of circulating CD8+ T cells that are specific for two of three investigated JARID1B HLA-A*0201 peptides PMID: 21105039
    48. JARID1B is the first TIEG1 corepressor identified, explaining how TIEG1 represses transcription through inducing histone H3 lysine 4 demethylation, which may be important for TIEG1 function in both normal and cancer cells. PMID: 20863814
    49. PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. PMID: 20832725
    50. The results from this study demonstrate that the flexible loop L1 of the human JARID1B ARID domain has a crucial role in DNA-binding activity. PMID: 20403335

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JARID1 histone demethylase family
  • 组织特异性：
    Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).
  • 数据库链接：

    HGNC: 18039

    OMIM: 605393

    KEGG: hsa:10765

    STRING: 9606.ENSP00000356234

    UniGene: Hs.18891