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KCTD12 Antibody

  • 中文名称：
    KCTD12兔多克隆抗体
  • 货号：
    CSB-PA012108GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96CX2
  • 基因名：
    KCTD12
  • 别名：
    tibody; BTB/POZ domain-containing protein KCTD12 antibody; KCD12_HUMAN antibody; KCTD12 antibody; KIAA1778 antibody; PFET1 antibody; Pfetin antibody; potassium channel tetramerisation domain containing 12 USA antibody; Predominantly fetal expressed T1 domain antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KCTD12
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
  • 基因功能参考文献：
    1. KCTD12 may exert its inhibitory role in ESCC through the suppression of WNT /NOTCH, stem cell factors, and chromatin remodelers and can be introduced as an efficient therapeutic marker. PMID: 30157793
    2. our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12. Thus, the KCTD12-CDC25B-CDK1-Aurora A axis has important implications for cancer diagnoses and prognoses. PMID: 28869606
    3. Low KCTD12 expression is associated with uveal melanoma. PMID: 28000887
    4. Studies determined that KCTD12 plays an important role in the tumorigenesis of colorectal cancer progression via activation of the ERK signaling pathway. PMID: 26847701
    5. N-terminal domain of KCTD12 assumes an alpha/beta structure, whereas the C-terminal domain is predominantly characterized by a beta-structure. PMID: 23996491
    6. KCTD12 is a useful and reliable biomarker for both the diagnosis and prognosis of gastrointestinal stromal tumor. PMID: 23290008
    7. This study provided that kctd12 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
    8. novel human gene, designated PFET1 (predominantly fetal expressed T1 domain) present in a variety of fetal organs, with highest expression levels in the cochlea and brain PMID: 15357420
    9. Pfetin is a powerful prognostic marker for gastrointestinal stromal tumors. PMID: 18347171

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  • 亚细胞定位：
    Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane.
  • 组织特异性：
    Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.
  • 数据库链接：

    HGNC: 14678

    OMIM: 610521

    KEGG: hsa:115207

    STRING: 9606.ENSP00000317141

    UniGene: Hs.644125