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KCNJ12 Antibody

  • 中文名称：
    KCNJ12兔多克隆抗体
  • 货号：
    CSB-PA619877LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of U251 cells with CSB-PA619877LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KCNJ12 Polyclonal antibody
  • Uniprot No.：
    Q14500
  • 基因名：
    KCNJ12
  • 别名：
    KCNJ12; IRK2; KCNJN1; ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+ channel Kir2.2; IRK-2; Inward rectifier K(+ channel Kir2.2v; Potassium channel, inwardly rectifying subfamily J member 12
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATP-sensitive inward rectifier potassium channel 12 protein (182-433aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KCNJ12 Antibody (CSB-PA619877LA01HU)，的标记方式是Non-conjugated。对于KCNJ12 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA619877LB01HU KCNJ12 Antibody, HRP conjugated ELISA
    FITC CSB-PA619877LC01HU KCNJ12 Antibody, FITC conjugated
    Biotin CSB-PA619877LD01HU KCNJ12 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
  • 基因功能参考文献：
    1. Cellular electrophysiology assays of mouse Kir2.1 and human Kir2.2 indicated that, consistent with simulations, the Leu residue increased the channel responses to phosphatidylinositol diphosphate (PIP2) through increased binding affinity and faster activation kinetics, and the deactivation kinetics decreased upon PIP2 inhibition. PMID: 26520451
    2. This report is the first to describe the KCNJ12 gene as a cause of familial dilated cardiomyopathy in patients PMID: 28816949
    3. The augmentation of Ca(2+) influx and cytokine release suggests a physiological role for Kir2.2 in TLR4-stimulated monocytes. PMID: 26324774
    4. Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer. PMID: 23269273
    5. Kir2.2 knockdown induces senescence of cancer cells by a mechanism involving reactive oxygen species accumulation. PMID: 20841375
    6. heteromerization contributes to the phenotype of Andersen syndrome PMID: 12032359
    7. Molecular cloning of functional KCNJ12 with an arginine residue at position 285. PMID: 12417321
    8. transcripts for Kir2.2 potassium channels are identified in proliferative smooth muscle cells PMID: 12598232
    9. Data show that the recovery of K(ir)2.2 from inhibition by FCCP requires intracellular components, but direct depletion of ATP does not reproduce the differential inhibitory effect of FCCP. PMID: 19016473

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ12 subfamily
  • 数据库链接：

    HGNC: 6258

    OMIM: 602323

    KEGG: hsa:3768

    STRING: 9606.ENSP00000328150

    UniGene: Hs.200629