Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. KCNIP4 Antibody

KCNIP4 Antibody

  • 货号：
    CSB-PA012046GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6PIL6
  • 基因名：
    KCNIP4
  • 别名：
    A type potassium channel modulatory protein 4 antibody; A-type potassium channel modulatory protein 4 antibody; CALP antibody; Calsenilin like protein antibody; Calsenilin-like protein antibody; HGNC:30083 antibody; KCHIP 4 antibody; KChIP4 antibody; KCIP4_HUMAN antibody; KCNIP 4 antibody; Kcnip4 antibody; Kv channel interacting protein 4 antibody; Kv channel-interacting protein 4 antibody; MGC44947 antibody; Potassium channel interacting protein 4 antibody; Potassium channel-interacting protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human KCNIP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
  • 基因功能参考文献：
    1. Results indicate that SNPs in KCNIP4 may modulate ACE inhibitor-induced cough risk. PMID: 26169577
    2. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4. PMID: 24811166
    3. genetic association studies in populations in Germany: Data suggest that multiple SNPs in KCNIP4 are associated not only with attention deficit disorder with hyperactivity in children and adults but also with personality disorders. PMID: 22981920
    4. Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse. PMID: 23457522
    5. KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation. PMID: 23576435
    6. The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels. PMID: 21624954
    7. These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a. PMID: 20045463
    8. cloning and investigation of interaction with presenilin 2 and voltage-gated potassium channel subunit Kv4 PMID: 11847232
    9. The conformational change with metal-bound KChIP4.1 is crucial for its interaction with Kv channel but not for KChIP2.2, and that the Mg2+- and Ca2+-binding properties of KChIP2.2 and KChIP4.1 have different effects on their molecular structure. PMID: 16951992
    10. Mutation of KCNIP4 is associated with renal cell carcinoma. PMID: 17981209
    11. CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases. PMID: 18269347
    12. These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. PMID: 18393943
    13. KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. PMID: 18957440

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 4]: Endoplasmic reticulum.
  • 蛋白家族：
    Recoverin family
  • 组织特异性：
    Predominantly expressed in brain.
  • 数据库链接：

    HGNC: 30083

    OMIM: 608182

    KEGG: hsa:80333

    STRING: 9606.ENSP00000371587

    UniGene: Hs.655705