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KCNH5 Antibody

  • 中文名称：
    KCNH5兔多克隆抗体
  • 货号：
    CSB-PA905787
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of 1) Rat Brain Tissue-Low Molecular Protein Marker, 2)Rat Brain Tissue-High Molecular Protein Marker, 3) Mouse Brain Tissue-Low Molecular Protein Marker, 4) Mouse Brain Tissue- High Molecular Protein Marker, 5) HepG2-Low Molecular P
    • Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using Kv10.2 Rabbit pAb diluted at 1:200.
    • Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using Kv10.2 Rabbit pAb diluted at 1:200.
  • 其他：

产品详情

  • Uniprot No.：
    Q8NCM2
  • 基因名：
    KCNH5
  • 别名：
    KCNH5 antibody; EAG2Potassium voltage-gated channel subfamily H member 5 antibody; Ether-a-go-go potassium channel 2 antibody; hEAG2 antibody; Voltage-gated potassium channel subunit Kv10.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-2000
    IHC 1:100-200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
  • 基因功能参考文献：
    1. EAG2 potassium channel has an evolutionarily conserved function for promoting brain tumor growth. PMID: 26258683
    2. The observed Ca(2+)-induced proteolytic cleavage of EAG2 channel may act as an adaptive response under physiological and/or pathological conditions. PMID: 25542181
    3. Study propose that hypomethylation of the placental-specific KCNH5 promoter is frequently associated with KCNH5 expression in melanoma cells. PMID: 24759919
    4. Our results demonstrate the critical role of the Arg327 residue in stabilizing the channel closed state and explicate for the first time the structural and functional change of a Kv10.2 channel mutation associated with neurological disease. PMID: 24133262
    5. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans. PMID: 23647072
    6. Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling PMID: 22792721
    7. molecular identification and characterisation PMID: 12135768
    8. Methylation of KCNH5 was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues. PMID: 18349282
    9. data suggest that the 'Per-Ant-Sim' (PAS) and cyclic nucleotide binding (cNBD) domains at the N- and C-termini form interacting oligomers that have roles in channel function PMID: 19172261

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.2/KCNH5 sub-subfamily
  • 组织特异性：
    Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney.
  • 数据库链接：

    HGNC: 6254

    OMIM: 605716

    KEGG: hsa:27133

    STRING: 9606.ENSP00000321427

    UniGene: Hs.27043