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KANK1 Antibody

  • 货号：
    CSB-PA614803LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA614803LA01HU diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) KANK1 Polyclonal antibody
  • Uniprot No.：
    Q14678
  • 基因名：
    KANK1
  • 别名：
    ANKRD 15 antibody; Ankyrin repeat domain 15 antibody; Ankyrin repeat domain containing protein 15 antibody; Ankyrin repeat domain-containing protein 15 antibody; DKFZp451G231 antibody; KANK antibody; KANK1 antibody; KANK1_HUMAN antibody; KIAA0172 antibody; Kidney ankyrin repeat containing protein antibody; Kidney ankyrin repeat-containing protein antibody; KN motif and ankyrin repeat domain-containing protein 1 antibody; MGC43128 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human KN motif and ankyrin repeat domain-containing protein 1 protein (66-255AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，KANK1 Antibody (CSB-PA614803LA01HU)，的标记方式是Non-conjugated。对于KANK1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA614803LB01HU KANK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA614803LC01HU KANK1 Antibody, FITC conjugated
    Biotin CSB-PA614803LD01HU KANK1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways.
  • 基因功能参考文献：
    1. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1. PMID: 29158259
    2. Low KANK1 expression is associated with lung cancer progression. PMID: 29956815
    3. KANK1 inhibits Malignant peripheral nerve sheath tumors cell growth though CXXC5 mediated apoptosis. PMID: 28067315
    4. Upregulating the Kank1 gene can inhibit the progress of gastric cancer. PMID: 28731169
    5. Here, the s show that cortical microtubule stabilization sites containing CLASPs, KIF21A, LL5beta and liprins are recruited to focal adhesions by the adaptor protein KANK1, which directly interacts with the major adhesion component, talin. Structural studies showed that the conserved KN domain in KANK1 binds to the talin rod domain R7. PMID: 27410476
    6. liprin beta-1 is associated with expression of kank 1 and 2 proteins in melanoma PMID: 26739330
    7. primary results revealed new function of Kank1 for nasopharyngeal cancer PMID: 25973051
    8. identified recessive mutations in kidney ankyrin repeat-containing protein 1 (KANK1), KANK2, and KANK4 in individuals with nephrotic syndrome. PMID: 25961457
    9. Thus, the human brain glioma apoptosis induced by upregulation of the Kank1 gene is closely relevant to the mitochondrial pathway. PMID: 24399197
    10. Our case suggests that KANK1 may be subject to random monoallelic expression as a possible mode of inheritance. PMID: 23454270
    11. ANKRD15 encodes the kidney ankyrin repeat-containing protein. PMID: 22876580
    12. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia. PMID: 20164854
    13. Kank is localized to 9p24 and plays a role in cell growth PMID: 12133830
    14. Human Kank gene has several alternative first exons. PMID: 15823577
    15. Kank can bind to beta-catenin and regulate the subcellular distribution of beta-catenin. PMID: 16968744
    16. Data suggest that Kank negatively regulates the formation of actin stress fibers and cell migration through the inhibition of RhoA activity, which is controlled by binding of Kank to 14-3-3 in PI3K-Akt signaling. PMID: 18458160
    17. These results suggest that KIF21A regulates the distribution of Kank1 and that KIF21A mutations associated with congenital fibrosis of the extraocular muscles type 1 enhanced the accumulation of Kank1 in the membrane fraction. PMID: 19559006

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  • 相关疾病：
    Cerebral palsy, spastic quadriplegic 2 (CPSQ2)
  • 亚细胞定位：
    Cell projection, ruffle membrane. Cytoplasm. Nucleus.; [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 组织特异性：
    Widely expressed. Isoform 1 is predominantly expressed in heart and kidney. Isoform 2 probably is widely expressed at basic levels.
  • 数据库链接：

    HGNC: 19309

    OMIM: 607704

    KEGG: hsa:23189

    STRING: 9606.ENSP00000371734

    UniGene: Hs.306764