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JUP Antibody

  • 货号：
    CSB-PA909861
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HT-29, MCF-7 and C2C12 cells using g-Catenin Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) JUP Polyclonal antibody
  • Uniprot No.：
    P14923
  • 基因名：
    JUP
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Peptide sequence around aa.726~730(I-D-T-Y-S) derived from Human g-Catenin
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • 基因功能参考文献：
    1. NEDD9, E-cadherin and gamma-catenin proteins have roles in pancreatic ductal adenocarcinoma PMID: 29924959
    2. gamma-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer. PMID: 28681073
    3. Data show that plakoglobin interacted with p53R175H and decreased beta-catenin protein levels. PMID: 29660231
    4. FBW7 cooperated with gamma-catenin to inhibit G2/M cell cycle transition and cell proliferation. PMID: 29408378
    5. These results suggest that a major role of 14-3-3gamma in desmosome assembly is to transport PG to the cell border leading to the initiation of desmosome formation. PMID: 29253567
    6. We showed that p53 and PG cooperatively reduced growth and acted synergistically to decrease cellular migration and invasion PMID: 27058623
    7. High plakoglobin expression is associated with lung adenocarcinoma. PMID: 26933815
    8. Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation PMID: 28943339
    9. Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP)/beta-catenin or gamma-catenin interaction. PMID: 28479420
    10. Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin PMID: 28158602
    11. In JUP mutations are the frequent cause of Arrhythmogenic cardiomyopathy, isolated Brugada syndrome can appear due to reduced sodium channel activities. PMID: 27389450
    12. investigated the in vitro tumor/metastasis suppressor effects of plakoglobin in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles PMID: 27144941
    13. Reduced plakoglobin staining in intercalated discs of heart tissue from human arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and in a murine ARVC model is caused by alterations in epitope accessibility and not by protein relocalization PMID: 26676851
    14. Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression. PMID: 26545977
    15. Immunostaining for plakoglobin might serve as an additional diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology. PMID: 25549959
    16. Expression of gamma-catenin in NSCLC cells resulted in reduced cell migration as determined by both scratch assays and trans-well cell migration assays. PMID: 25925948
    17. Six variants of uncertain clinical significance in the PKP2, JUP, and DSG2 genes showed a deleterious effect on mRNA splicing, indicating these are ARVD/C-related pathogenic splice site mutations. PMID: 25087486
    18. gamma-catenin is a tumor suppressor in esophageal squamous cell carcinoma and may serve as a prognostic marker PMID: 24914344
    19. Immunohistochemical analysis of plakoglobin had a relatively high sensitivity and specificity in arrhythmogenic right ventricular cardiomyopathy, but could not be relied upon as a diagnostic test for ARVC. PMID: 24294380
    20. extranuclear plakoglobin has a role in controlling cell adhesion via p38MAPK-dependent regulation of keratin filament organization PMID: 24441103
    21. Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion. PMID: 24260116
    22. Reduced immunoreactive signal of JUP at the intercalated disks can be observed in a majority of ARVD-C patients. PMID: 23688911
    23. redistribution of JUP from the cell membrane to the nucleus not only has the potential to serve as a diagnostic marker for ARVC but also might provide insights into its pathogenesis PMID: 23806441
    24. The combination of gamma-catenin and Twist positive staining is associated with poor prognosis in malignant pleural mesothelioma. PMID: 24457449
    25. data indicate that the AhR may contribute to negative regulation of Jup gene expression in rodent cellular models, which may affect cell adherence and proliferation PMID: 23690540
    26. analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells PMID: 23583905
    27. this data suggest that plakoglobin regulates gene expression in conjunction with p53 and that plakoglobin may regulate p53 transcriptional activity, which may account, in part, for the tumor/metastasis suppressor activity of plakoglobin. PMID: 23687381
    28. Downregulation of catenin gamma by siRNA inhibited the proliferation and colony formation of chronic myeloid leukemia cells. PMID: 23233089
    29. Gamma-catenin compensates for beta-catenin loss at adherens junctions without affecting desmosomes but is unable to fulfill functions in Wnt signaling. PMID: 23555187
    30. A reduced immunoreactive signal of PKG, Cx43, and NaV1.5 at the intercalated disks can be observed in a large majority of the patients. PMID: 23178689
    31. CD133 interacts with plakoglobin and knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2. PMID: 23326490
    32. Data indicate that plakoglobin and isoforms were present in atherosclerotic plaques and their secretomes. PMID: 23110151
    33. Overexpression of gamma-catenin is associated with stabilization and nuclear localization of beta-catenin resulting in acute myeloid leukemia. PMID: 22858986
    34. Data show that E-cadherin and alpha-catenin were predominantly expressed in the cell membranes, whereas beta- and gamma-catenin were found both in the cell membrane and cytoplasm. PMID: 20933443
    35. The presence of beta and gamma catenin, particularly in osteoblasts, demonstrates a significant role of catenins in functions such as signaling and activation of transcription factors during differentiation of bone tissues PMID: 21781455
    36. PG may inhibit Src by keeping VN low. Our results suggest that loss of intercellular adhesion due to reduced PG expression might be exacerbated by activation of Src through a PG-dependent mechanism PMID: 22860065
    37. Rnd3 regulates desmosome function and keratinocyte cell death via a plakoglobin-dependent mechanism. PMID: 22454524
    38. Gastroesophageal reflux disease was specifically associated with elevated transcript levels of desmoglein 2 and plakoglobin PMID: 22521077
    39. This study thus implicates SLUG-induced repression of plakoglobin as a motility determinant in highly disseminating breast cancer. PMID: 22496452
    40. Induced gene expression levels of plakoglobin, desmoglein-1 and desmoglein-2 correlated significantly with dilatation of intercellular spaces and basal cell hyperplasia in esophageal mucosa of patients with gastro-oesophageal reflux disease. PMID: 22276604
    41. Lack of plakoglobin in epidermis leads to keratoderma. PMID: 22315228
    42. the junctional protein plakoglobin is a key regulator of cell-cell contact,which may be a fundamental control mechanism governing cell viability PMID: 22046445
    43. The junction plakoglobin (JUP) interacts with SOX4 in both the cytosol and the nucleus and the interaction between SOX4 and plakoglobin is significantly increased when prostate and breast cancer cells are stimulated with WNT3A. PMID: 22098624
    44. Junction plakoglobin (JUP) interacts with SOX4 in both the cytosol and the nucleus and the interaction between SOX4 and plakoglobin is significantly increased when prostate and breast cancer cells are stimulated with WNT3A. PMID: 22098624
    45. Disease mechanisms, involving desmosomal proteins (such as plakoglobin) in granulomatous myocarditis, and implicating cytokines, are involved in the disruption of desmosomal proteins and arrhythmogenesis in arrhythmogenic right ventricular cardiomyopathy. PMID: 21859801
    46. plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation PMID: 20859650
    47. investigation of role of gamma catenin and CBP (CREB-Binding Protein) in regulation of transcription of survivin PMID: 21158719
    48. sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 are differently regulated in medulloblastoma and astrocytoma PMID: 21059263
    49. Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1. PMID: 21075858
    50. Studies identified two mutations in DSG2, four in DSC2, two in DSP, four in JUP and seven in PKP2. PMID: 20864495

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  • 相关疾病：
    Naxos disease (NXD); Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12)
  • 亚细胞定位：
    Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form.
  • 蛋白家族：
    Beta-catenin family
  • 数据库链接：

    HGNC: 6207

    OMIM: 173325

    KEGG: hsa:3728

    STRING: 9606.ENSP00000311113

    UniGene: Hs.514174