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JPH1 Antibody

  • 货号：
    CSB-PA872553LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA872553LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system.
    • Immunofluorescence staining of Hela cells with CSB-PA872553LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) JPH1 Polyclonal antibody
  • Uniprot No.：
    Q9HDC5
  • 基因名：
    JPH1
  • 别名：
    DKFZp762L0313 antibody; JP 1 antibody; JP-1 antibody; JP1 antibody; JPH 1 antibody; JPH1 antibody; JPH1_HUMAN antibody; Junctophilin 1 antibody; Junctophilin type 1 antibody; Junctophilin type1 antibody; Junctophilin-1 antibody; Junctophilin1 antibody; Mitsugumin 72 antibody; Mitsugumin72 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Junctophilin-1 protein (431-546AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，JPH1 Antibody (CSB-PA872553LA01HU)，的标记方式是Non-conjugated。对于JPH1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872553LB01HU JPH1 Antibody, HRP conjugated ELISA
    FITC CSB-PA872553LC01HU JPH1 Antibody, FITC conjugated
    Biotin CSB-PA872553LD01HU JPH1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
  • 基因功能参考文献：
    1. This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
    2. This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period PMID: 23148318
    3. JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery PMID: 22020936
  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Junctophilin family
  • 组织特异性：
    Abundantly expressed in skeletal muscle. Very low levels in heart.
  • 数据库链接：

    HGNC: 14201

    OMIM: 605266

    KEGG: hsa:56704

    STRING: 9606.ENSP00000344488

    UniGene: Hs.657367