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JMJD1C Antibody

  • 货号：
    CSB-PA624030HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA624030HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA624030HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) JMJD1C Polyclonal antibody
  • Uniprot No.：
    Q15652
  • 基因名：
    JMJD1C
  • 别名：
    JHD2C_HUMAN antibody; Jmjd1c antibody; Jumonji domain containing 1C antibody; Jumonji domain-containing protein 1C antibody; Probable JmjC domain-containing histone demethylation protein 2C antibody; Thryoid receptor interacting protein antibody; Thyroid receptor-interacting protein 8 antibody; TR-interacting protein 8 antibody; TRIP-8 antibody; TRIP8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Probable JmjC domain-containing histone demethylation protein 2C protein (539-648AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，JMJD1C Antibody (CSB-PA624030HA01HU)，的标记方式是Non-conjugated。对于JMJD1C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA624030HB01HU JMJD1C Antibody, HRP conjugated ELISA
    FITC CSB-PA624030HC01HU JMJD1C Antibody, FITC conjugated
    Biotin CSB-PA624030HD01HU JMJD1C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes.
  • 基因功能参考文献：
    1. Study provides evidence that SNPs of JMJD1C and KCNQ1 are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40. PMID: 28406950
    2. JMJD1C is one of the target genes of hsa-miR-590- 3p. PMID: 27064872
    3. Our findings indicate that mutations in JMJD1C contribute to the development of Rett syndrome and intellectual disability. PMID: 26181491
    4. genetic variants in the androgen-related genes CYP17A1 and JMJD1C might be associated with risk of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). PMID: 26414697
    5. Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
    6. JMJD1C is directly recruited by RUNX1-RUNX1T1 to its target genes and regulates their expression by maintaining low H3K9 dimethyl (H3K9me2) levels PMID: 26494788
    7. Depletion of JMJD1C impairs expansion and colony formation of leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM. PMID: 24501218
    8. JMJD1C represses neural differentiation of hESCs at least partially by epigenetically sustaining miR-302 expression PMID: 24318875
    9. JMJD1C regulates the RAP80-BRCA1 branch of this DNA-damage response (DDR) pathway. PMID: 24240613
    10. No evidence for JMJD1C histone demethylase activity towards H3K9. PMID: 23593242
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20648472
    12. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
    14. TRIP8 gene codes for a protein predicted to be a transcriptional regulator associated with nuclear thyroid hormone receptors. Positional candidate gene for autism. PMID: 17290275
    15. the discovery of a new Receptors, Androgen coactivator which belongs to the JmjC containing enzyme family as a novel variant of JMJD1C PMID: 17353003
    16. Human JMJD1C variant 2 with TRI8H1, TRI8H2, and JmjC domains showed 85.7% total-amino-acid identity with mouse Jmjd1c. PMID: 17549425
    17. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19936222
    18. Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451
    19. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18940312

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM2 histone demethylase family
  • 数据库链接：

    HGNC: 12313

    OMIM: 604503

    KEGG: hsa:221037

    STRING: 9606.ENSP00000382204

    UniGene: Hs.413416