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JDP2 Antibody

  • 货号：
    CSB-PA006988
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using JDP2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8WYK2
  • 基因名：
    JDP2
  • 别名：
    Jdp2 antibody; JDP2_HUMAN antibody; Jun dimerization protein 2 antibody; JUNDM2 antibody; Progesterone receptor co-activator antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human JDP2 around the non-phosphorylation site of T148.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
  • 基因功能参考文献：
    1. In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival. PMID: 28315425
    2. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells. PMID: 24120378
    3. Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE. PMID: 24232097
    4. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. PMID: 22989952
    5. The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed. PMID: 20950777
    6. JDP2 is crucial to triggering reactivation from latency to lytic replication PMID: 21525011
    7. 3 SNPs (2 intronic: rs741846 & rs175646; & 1 in the untranslated region: rs8215) & their genotype distribution showed significant association in the Japanese & Korean but not Dutch intracranial aneurysm patients. PMID: 20452405
    8. JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival. PMID: 20677166
    9. c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene PMID: 14627710
    10. JDP2 is a cellular survival protein whose presence is necessary for normal cellular function PMID: 16026868
    11. JDP2 acts as a repressor and could be functionally associated with HDAC3 to inhibit CHOP transcription PMID: 18396163
    12. IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter. PMID: 18671972
    13. A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain. PMID: 19553667

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 数据库链接：

    HGNC: 17546

    OMIM: 608657

    KEGG: hsa:122953

    STRING: 9606.ENSP00000267569

    UniGene: Hs.196482