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JAM2 Antibody

  • 货号：
    CSB-PA004796
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using JAM-B Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P57087
  • 基因名：
  • 别名：
    C21orf43 antibody; CD 322 antibody; CD322 antibody; CD322 antigen antibody; JAM 2 antibody; JAM B antibody; JAM IT/VE JAM antibody; JAM; vascular endothelial antibody; JAM-2 antibody; JAM-B antibody; JAM2 antibody; JAM2_HUMAN antibody; JAMB antibody; Jcam2 antibody; Junction adhesion molecule 2 antibody; Junction adhesion molecule B antibody; Junctional adhesion molecule 2 antibody; Junctional adhesion molecule B antibody; PRO 245 antibody; PRO245 antibody; Vascular endothelial junction associated molecule antibody; Vascular endothelial junction-associated molecule antibody; VE JAM antibody; VE-JAM antibody; VEJAM antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human JAM-B.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.
  • 基因功能参考文献：
    1. this review briefly focuses on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer. [review] PMID: 27121546
    2. JAM-2 may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer PMID: 26782073
    3. This study showed thatJAM2 (rs2829841; intronic), associated with Alzheimer disease. PMID: 25649652
    4. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PMID: 24357068
    5. These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma PMID: 23277282
    6. role as an adhesive ligand for interacting with a variety of immune cell types PMID: 11823489
    7. interacts with alpha4beta1; Facilitation by JAM3 PMID: 12070135
    8. Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells PMID: 12476045
    9. Examine JAM-2 expression in normal/inflammed lymphatic endothelium. PMID: 17822725
    10. Discovery as ligand for the integrin alpha4beta1 PMID: 12070135
    11. Cloning and discovery as adhesion receptor for T cells PMID: 10945976

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Highly expressed in heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level). Also expressed in the brain in the caudate nuclei.
  • 数据库链接：

    HGNC: 14686

    OMIM: 606870

    KEGG: hsa:58494

    STRING: 9606.ENSP00000420419

    UniGene: Hs.517227