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IZUMO1 Antibody

  • 货号：
    CSB-PA812903LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA812903LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA812903LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IZUMO1 Polyclonal antibody
  • Uniprot No.：
    Q8IYV9
  • 基因名：
    IZUMO1
  • 别名：
    FLJ61440 antibody; IZUM1_HUMAN antibody; IZUMO antibody; Izumo sperm egg fusion 1 antibody; Izumo sperm-egg fusion protein 1 antibody; Izumo1 antibody; MGC34799 antibody; OBF antibody; Oocyte binding/fusion factor antibody; Sperm specific protein izumo antibody; Sperm-specific protein izumo antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IZUMO1 Antibody (CSB-PA812903LA01HU)，的标记方式是Non-conjugated。对于IZUMO1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA812903LB01HU IZUMO1 Antibody, HRP conjugated ELISA
    FITC CSB-PA812903LC01HU IZUMO1 Antibody, FITC conjugated
    Biotin CSB-PA812903LD01HU IZUMO1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
  • 基因功能参考文献：
    1. crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction PMID: 27309808
    2. crystal structures of human IZUMO1 and JUNO in unbound and bound conformations PMID: 27309818
    3. these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein. PMID: 23279005
    4. human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs [Izumo] PMID: 15759005
    5. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions. PMID: 18082733
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 18082733

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Izumo family
  • 组织特异性：
    Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
  • 数据库链接：

    HGNC: 28539

    OMIM: 609278

    KEGG: hsa:284359

    STRING: 9606.ENSP00000327786

    UniGene: Hs.400688