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ITGB6 Antibody

  • 货号：
    CSB-PA160596
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA160596(ITGB6 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA160596(ITGB6 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P18564
  • 基因名：
  • 别名：
    ITGB6; Integrin beta-6
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ITGB6
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1.
  • 基因功能参考文献：
    1. these findings demonstrate that JunB and CBP-mediated histone hyperacetylation are responsible for TGF-beta1 induced ITGB6 transcription in oral squamous cell carcinoma (OSCC) cells, suggesting that epigenetic mechanisms are responsible for the active transcription expression of ITGB6 induced by TGF-beta1 in OSCC cells. PMID: 29274289
    2. Taken together, our results indicate that integrin beta6 promotes tumor invasiveness in a Rac1-dependent manner and is a potential biomarker for tumor metastasis. PMID: 27440504
    3. The increased regional and distant metastasis observed in HER2+ tumors with high levels of ITGB6 might be mediated by the canonical Rho-Rac pathway through increased expression of MMP9 and MMP15. PMID: 27184932
    4. Rare missense variant c.898G>A (p.(Glu300Lys)) in ITGB6 causes not only dentogingival anomalies but also intellectual disability and alopecia. PMID: 26695873
    5. Treatment of these cells with the dual-specificity tyrosine-kinase inhibitor lapatinib led to downregulation of epithelial-to-mesenchymal transition as indicated by lower levels of SNAI1 and SNAI2 transcripts, integrin AVB6, and matrix metalloproteinase 9 protein PMID: 28349782
    6. Integrin b6 markedly promoted the proliferation and invasion of pancreatic carcinoma cells and induced ETS1 phosphorylation in an ERK-dependent manner, leading to the upregulation of matrix metalloprotease-9, which is essential for b6-mediated invasiveness of pancreatic carcinoma cells PMID: 26547582
    7. AG/GG genotypes of ITGB6 rs4665162 gene were associated with a higher risk of radiation pneumonitis (RP) in patients with lung cancer receiving radiotherapy and thus may serve as a reliable predictor of RP. PMID: 26449830
    8. A novel homozygous ITGB6 mutation causing isolated amelogenesis imperfecta, and this advances the understanding of normal and pathologic enamel development. PMID: 25431241
    9. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. PMID: 26861876
    10. Integrin beta6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas PMID: 24844802
    11. The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period PMID: 26134759
    12. Results shows that ITGB6 promoter contains a functional TATA box and that STAT3 and C/EBPalpha are involved in its positive regulation in oral squamous cell carcinoma cells. PMID: 25816241
    13. targeting eIF4E in integrin ava6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer. PMID: 25982998
    14. In conclusion NSCLC cell lines, positive for E-Cadherin,EpCAM and avb6 expression, activate normal fibroblasts through avbeta6/TGFbeta signalling in vitro, and influence both gene expression and response to therapeutic agents. PMID: 24488011
    15. The deficiency of avb6-related hyperpermeability in T84 monolayers could be compensated by adding exogenous avb6 to the culture. PMID: 24677750
    16. Expression of the alphavbeta6 integrin subunit seems to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases. PMID: 25150423
    17. ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta. PMID: 24305999
    18. Brain metastases ITGB6 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
    19. ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with alphavbeta6 integrin PMID: 24055471
    20. Data indicate that integrin beta6, CD46, tissue factor, and chromosome 14 open reading frame 1 (C14ORF1), were identified as overexpressed on pancreatic cancer cell lines. PMID: 21934552
    21. These data identify a novel interaction between Psor and beta6 and demonstrate that it is required for alphavbeta6-dependent invasion by carcinoma cells. PMID: 21132011
    22. Integrin beta6 plays a role in the compromised wound healing associated with the diabetic state. PMID: 20854469
    23. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8. PMID: 19920174
    24. Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit PMID: 11992542
    25. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema PMID: 12634787
    26. upon ligation of integrin beta6 with fibronectin, beta6 complexed with Fyn and activated it, activating a pathway leading to activation of the matrix metalloproteinase-3 gene, and promoting oral SCC cell proliferation and experimental metastasis in vivo PMID: 12917446
    27. beta(6) integrin is not normally expressed in adult native or transplanted kidneys but is commonly up-regulated in the distal tubule in disease. PMID: 15458435
    28. Constitutively activated STAT3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through ITGB6. PMID: 17438134

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  • 相关疾病：
    Amelogenesis imperfecta 1H (AI1H)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
  • 蛋白家族：
    Integrin beta chain family
  • 数据库链接：

    HGNC: 6161

    OMIM: 147558

    KEGG: hsa:3694

    STRING: 9606.ENSP00000283249

    UniGene: Hs.470399