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ITGAD Antibody

  • 货号：
    CSB-PA005837
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 4T1, 293 cells using Integrin αD Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q13349
  • 基因名：
  • 别名：
    ITGAD antibody; Integrin alpha-D antibody; ADB2 antibody; CD11 antigen-like family member D antibody; Leukointegrin alpha D antibody; CD antigen CD11d antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Integrin αD.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.
  • 基因功能参考文献：
    1. findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development. PMID: 28500072
    2. These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease. PMID: 27881604
    3. alpha(D)beta(2) is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans PMID: 25415295
    4. The effects of anti-CD11d treatment improves functional recovery in a rat model of repeated concussion. PMID: 23414334
    5. the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively. PMID: 21712539
    6. CD11d expression increased in the subcutaneous white adipose tissue of obese adult women; this appears to be a common feature of obesity. PMID: 21508205
    7. a longer isoform of gut-enriched Kruppel-like factor 4 (GKLF) we term GKLFa interacts with the CD11d promoter PMID: 15561714
    8. multiple CD11d domains play a role in controlling intracellular location and association with CD18. PMID: 19571252

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 组织特异性：
    Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
  • 数据库链接：

    HGNC: 6146

    OMIM: 602453

    KEGG: hsa:3681

    STRING: 9606.ENSP00000373854

    UniGene: Hs.679163