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ITGA9 Antibody

  • 货号：
    CSB-PA619792ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA619792ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA619792ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ITGA9 Polyclonal antibody
  • Uniprot No.：
    Q13797
  • 基因名：
  • 别名：
    Alpha RLC antibody; Integrin alpha 4 like antibody; Integrin alpha RLC antibody; Integrin alpha-9 antibody; Integrin alpha-RLC antibody; ITA9_HUMAN antibody; ITGA 4L antibody; ITGA 9 antibody; ITGA4L antibody; ITGA9 antibody; RLC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Integrin alpha-9 protein (30-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
  • 基因功能参考文献：
    1. ITGA9 expression was found to be increased in the suprabasal psoriatic epidermis. PMID: 28844950
    2. Our data suggest ITGA9, as a suppressor of HCC, prevents tumor cell migration and invasiveness through FAK/Src-Rac1/RhoA signaling. PMID: 29951557
    3. this study demonstrates the central role of alpha9 in pathogenic behaviors of rheumatoid arthritis fibroblast-like synoviocytes PMID: 29038247
    4. Metastatic prostate cancer cells cultured on osteo-mimetic surfaces coated with tenascin C exhibited enhanced adhesion and colony formation as mediated by integrin alpha9beta1. PMID: 28916657
    5. the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples PMID: 27287342
    6. our results demonstrate that upregulation of ITGA9 in response to the decrease in miR-125b in metastatic melanoma is responsible for melanoma tumor cell migration and invasion. PMID: 26596831
    7. ITGA9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma. PMID: 26372814
    8. p75(NTR) and alpha9 integrin subunit are not closely associated through their cytoplasmic domains, most probably because of the molecular interference with other cytoplasmic proteins such as paxillin. PMID: 25748048
    9. alpha9beta1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. PMID: 24241034
    10. rs189897 and rs2212020 genotypes of the ITGA9 are closely related to cerebral infarction, and the A-C haplotype is a protective factor against cerebral infarction. PMID: 21764681
    11. integrin alpha9beta1 is expressed in primary small cell lung cancer and patients having a high expression of alpha9beta1 demonstrated significantly worse long-term survival compared with patients with low alpha9beta1 expression PMID: 22370635
    12. Neuronal cadherin and alpha9-integrin are postulated as leading actors in the association between the Notch pathway and promotion of cell adhesion, motility and invasion in rhabdomyosarcoma cells PMID: 22976797
    13. expression of alpha9beta1 in breast cancer; alpha9beta1 acts as novel marker of basal-like breast cancer subtype; expression associated with reduced survival; its ability to promote cell migration and invasion suggests it contributes to aggressiveness of this subtype PMID: 21341269
    14. Differential capacity for VEGF-D production and integrin alpha 9 beta 1 expression by human breast cancer cell line MDA-MB-468LN jointly contributed to their lymphatic metastatic phenotype. PMID: 22545097
    15. Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors PMID: 21975548
    16. endostatin reduces colorectal tumor-induced lymphangiogenesis, at least in part, by inhibiting EDA-integrin alpha9 pathway. PMID: 21465533
    17. the three-amino acid sequence, EYP, encoded by exon 3 of VEGF-A is essential for binding of VEGF to integrin alpha9beta1 and induces adhesion and migration of endothelial and cancer cells PMID: 21071450
    18. dysregulation of hMLH1, ITGA9, and RBSP3 associated multiple cellular pathways are needed for the development of early dysplastic lesions of the head and neck. PMID: 20412120
    19. up-regulation of alpha9beta1 expression among all beta1 integrins during neutrophil activation and transendothelial migration and a synergy between alpha9beta1 and beta2 integrins in stabilizing neutrophil adhesion to endothelium under flow conditions PMID: 20435742
    20. Data show that alpha9beta1 integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis, and that these effects are dependent on the activation of PI3K and MAPK pathways. PMID: 20362630
    21. Expression and activation of alpha9 integrin greatly enhances the ability of retinal pigment epithelial cells to adhere to wet age-related macular degeneration-affected Bruch's membranes. PMID: 20159768
    22. A genetic variation(s) in ITGA9 may influence susceptibility to nasopharyngeal carcinoma in the Malaysian Chinese population. PMID: 19478819
    23. although alpha9beta1 integrin can induce and localise to focal adhesions in a high activation state, its intermediate activity state normally supports cell adhesion consistent with migration. PMID: 19796635
    24. role in chemotaxis in conjuction with plasmin PMID: 15247268
    25. spermidine acetyltransferase directly binds to the alpha9 cytoplasmic domain and mediates alpha9-dependent enhancement of cell migration PMID: 15479742
    26. VEGF-C and VEGF-D are ligands for the integrin alpha9beta1 PMID: 15590642
    27. Data found that alpha9beta1 is a receptor for nerve growth factor and two other neurotrophins, and interaction of alpha9beta1 with NGF was confirmed in an ELISA assay by direct binding to purified integrin. PMID: 18230652
    28. tumor-cell expressions of alpha9 and beta1 integrins in combination with extracellular tenascin are necessary for medulloblastoma adhesion to the leptomeninges. PMID: 18794852
    29. Possible link between ITGA9 missens mutation and human fetuses with severe chylothorax. PMID: 18973153
    30. Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer PMID: 19140316
    31. Polymerization of OPN generates a novel alpha9beta1-binding site and that the interaction of this site with the alpha9beta1 integrin is critical to the neutrophil chemotaxis induced by polymeric OPN. PMID: 19346516
    32. After forced expression of alpha9 integrin, extensive neurite outgrowth from PC12 cells and adult rat dorsal root ganglion neurons occurs. PMID: 19403822
    33. Inhibition of alpha(9) integrin function with an anti-alpha(9) integrin Ab significantly reduces the production of arthrogenic cytokines and chemokines and ameliorates ongoing arthritis PMID: 19494327
    34. The integrin alpha9beta1 is expressed on hematopoietic stem cells, and contributes to adhesion and differentiation of hematopoietic stem cells in the endosteal stem cell niche PMID: 19608669
    35. Results reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects. PMID: 19686679

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 组织特异性：
    In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
  • 数据库链接：

    HGNC: 6145

    OMIM: 603963

    KEGG: hsa:3680

    STRING: 9606.ENSP00000264741

    UniGene: Hs.113157