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IRX4 Antibody

  • 货号：
    CSB-PA011836LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, Jurkat whole cell lysate, Colo320 whole cell lysate
      All lanes: IRX4 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 55, 58 kDa
      Observed band size: 55 kDa
    • Immunofluorescence staining of MCF-7 cells with CSB-PA011836LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品描述：

    The IRX4 antibody can be used to recognize the human IRX4 protein. A rabbit got immunization with the recombinant human IRX4 protein (287-363aa). After that, an immune response occurred in the rabbit producing large amounts of antibodies against the IRX4 protein. The rabbit's blood was collected and isolated to get the anti-serum, which was protein G-purified to obtain the IRX4 polyclonal antibody (purity 95%+). This IRX4 antibody has accessed its specificity in ELISA, WB, and IF applications.

    The IRX4 plays a crucial role in cardiac development and is essential for proper heart function. Specifically, IRX4 is involved in regulating the differentiation of cardiac conduction cells, which are specialized cells that help coordinate the rhythmic contraction of the heart muscle. Mutations in IRX4 have been linked to several heart conditions, including atrial fibrillation and ventricular tachycardia.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IRX4 Polyclonal antibody
  • Uniprot No.：
    P78413
  • 基因名：
    IRX4
  • 别名：
    Homeodomain protein IRXA3 antibody; Iroquois homeobox protein 4 antibody; Iroquois-class homeodomain protein IRX-4 antibody; Iroquoisclass homeodomain protein IRX4 antibody; Irx4 antibody; IRX4_HUMAN antibody; IRXA3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Iroquois-class homeodomain protein IRX-4 protein (287-363AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IRX4 Antibody (CSB-PA011836LA01HU)，的标记方式是Non-conjugated。对于IRX4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011836LB01HU IRX4 Antibody, HRP conjugated ELISA
    FITC CSB-PA011836LC01HU IRX4 Antibody, FITC conjugated
    Biotin CSB-PA011836LD01HU IRX4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Likely to be an important mediator of ventricular differentiation during cardiac development.
  • 基因功能参考文献：
    1. We independently validated IRX4 as a potential prostate cancer risk gene through cis-expression quantitative trait loci analysis of prostate cancer risk variants. PMID: 24022300
    2. the prostate cancer (PC)-susceptibility locus represented by rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility PMID: 22323358
    3. IRX4 had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect. PMID: 21544582
    4. Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID: 21779381
    5. Polymorphism A381>G of the Irx4 gene may have a modifier effect on septal thickness, resulting in increased corrected QT dispersion and higher outflow gradients. PMID: 18497553

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 组织特异性：
    Predominantly expressed in cardiac ventricles.
  • 数据库链接：

    HGNC: 6129

    OMIM: 606199

    KEGG: hsa:50805

    STRING: 9606.ENSP00000231357

    UniGene: Hs.196927