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  4. IRS4 Antibody

IRS4 Antibody

  • 货号：
    CSB-PA294860
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA294860(IRS4 Antibody) at dilution 1/17, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O14654
  • 基因名：
  • 别名：
    IRS4 antibody; Insulin receptor substrate 4 antibody; IRS-4 antibody; 160 kDa phosphotyrosine protein antibody; py160 antibody; Phosphoprotein of 160 kDa antibody; pp160 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human IRS4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    IHC 1:20-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
  • 基因功能参考文献：
    1. increase of IRS-4 expression may be involved to some extent in colorectal cancer. PMID: 29185229
    2. IRS4 overexpression is associated with cancer. PMID: 27869826
    3. these results demonstrated that miR-493 acts as a tumor suppressor and inhibits cell proliferation and cell cycle in human melanoma by directly targeting IRS4. PMID: 28475006
    4. The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions. PMID: 25100728
    5. Overexpression of IRS4 in U2OS cells activates PI3K signalling. PMID: 24039912
    6. We genotyped single-nucleotide polymorphisms of IGF1, IGF2, IGF1R, IGF2R, IGFBP1, IGFBP3, IGFBP5, IRS1, IRS2, and IRS in pancreatic cancer patients PMID: 21852217
    7. This study clearly demonstrates associations between body mass index and IRS-4 variants in schizophrenia patients, but not in healthy controls, pointing to a possible involvement of IRS-4 in the control of body weight in schizophrenia. PMID: 22167131
    8. Study for the first time identified IRS4 mutations in T-ALL. PMID: 21517825
    9. IRS-4 gene is not of importance for aetiology of the vast majority of schizophrenia cases, but a single patient with schizophrenia and a mutation in IRS-4 points to that the insulin signalling system is of interest in the search for schizophrenia genes PMID: 21407155
    10. The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4. PMID: 20340132
    11. Insulin receptor substrate 4 associates with the protein IRAS PMID: 11912194
    12. IRS-4 does not function as a substrate of the insulin and the IGF-I receptor in primary muscle cells but may be involved in nonreceptor tyrosine kinase signaling. PMID: 12639902
    13. data demonstrate cell-specific alterations in IRS protein concentrations in theca cells from polycystic ovaries consistent with exaggerated amplification of the insulin signal & which may play a role in ovarian hyperandrogenism & thecal hyperplasia PMID: 15155816
    14. insulin receptor substrate-4 and ShcA have roles in signaling by the fibroblast growth factor receptor PMID: 15316024
    15. IRS-4 is subject to regulation by TNF-alpha, and PP4 mediates TNF-alpha-induced degradation of IRS-4 PMID: 15331607
    16. endogenous Brk and IRS-4 interact in A431 human epidermoid carcinoma cells PMID: 15870689
    17. IRS-4 plays an important role in HepG2 proliferation/differentiation and exerts its actions through ERK and p70S6K activation in a ras/raf/MEK1/2- and PI3Kinase/Akt-independent manner and in a PKC-dependent way PMID: 17408801
    18. Transgenic rat gene WDR6 interacts with insulin receptor substrate 4 (IRS-4) in the rat brain and may participate in signaling and regulation of feeding behavior and longevity in the brain. PMID: 17720279
    19. 53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates. PMID: 17965023
    20. Data demonstrate that IRS4 interacts with the LR. This recruitment is leptin dependent and requires phosphorylation of the Y1077 motif of the LR. PMID: 18165436
    21. The association and altered regulation of IRS proteins by Ad5E1A contribute to the adenovirus-transformed phenotype and modulates viral infection in an Akt-dependent manner. PMID: 19029952

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 组织特异性：
    Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma.
  • 数据库链接：

    HGNC: 6128

    OMIM: 300904

    KEGG: hsa:8471

    STRING: 9606.ENSP00000361202

    UniGene: Hs.407141