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IRF2BP2 Antibody

  • 中文名称：
    IRF2BP2兔多克隆抗体
  • 货号：
    CSB-PA011817GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z5L9
  • 基因名：
    IRF2BP2
  • 别名：
    I2BP2_HUMAN antibody; Interferon regulatory factor 2 binding protein 2 antibody; Interferon regulatory factor 2-binding protein 2 antibody; IRF-2-binding protein 2 antibody; IRF-2BP2 antibody; IRF2 binding protein 2 antibody; IRF2BP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human IRF2BP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation.
  • 基因功能参考文献：
    1. In the Title. PMID: 27872498
    2. A novel IRFBP2 mutation was identified in a family with autosomal dominant CVID. Transduction experiments suggest that the mutant protein has an effect on B-cell differentiation and is likely a monogenic cause of the family's CVID phenotype. PMID: 27016798
    3. ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation. PMID: 26593974
    4. A deletion variant that lowers IRF2BP2 expression predisposes to coronary artery disease in humans. PMID: 26195219
    5. analysis of an IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma PMID: 23185413
    6. Nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS. Changes in phosphorylation status likely control nucleocytoplasmic localization of IRF2BP2 during muscle differentiation. PMID: 21887377
    7. results indicate that DIF-1 plays a key role in breast cancer cell survival PMID: 19190336
    8. Data demonstrate that IRF-2BP2 is a negative regulator of the NFAT1 transcription factor and suggest that NFAT1 repression occurs at the transcriptional level. PMID: 21576369
    9. IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles. PMID: 20702774
    10. IRF2BP2 works with TEAD transcription factors to upregulate the expression of VEGFA in skeletal and cardiac muscle. IRF2BP2 protein levels are increased in response to tissue ischemia. PMID: 20702774
    11. Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2. PMID: 12799427

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    IRF2BP family
  • 数据库链接：

    HGNC: 21729

    OMIM: 615332

    KEGG: hsa:359948

    STRING: 9606.ENSP00000355568

    UniGene: Hs.350268