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IRAK3 Antibody

  • 货号：
    CSB-PA006792
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of LOVO cells using IRAK-M Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y616
  • 基因名：
  • 别名：
    ASRT5 antibody; IL 1 receptor associated kinase M antibody; IL-1 receptor-associated kinase M antibody; IL1 receptor associated kinase M antibody; Interleukin 1 receptor associated kinase 3 antibody; Interleukin 1 receptor associated kinase M antibody; Interleukin-1 receptor-associated kinase 3 antibody; IRAK M antibody; IRAK-3 antibody; IRAK-M antibody; Irak3 antibody; IRAK3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human IRAK-M.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
  • 基因功能参考文献：
    1. Clinical trial with house dust mite allergen challenge of asthmatic patients reveal that IRAK-M is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. PMID: 29686383
    2. Rs11541076 in IRAK3, a negative regulator of TLR signalling, as a predictor of anti-TNF treatment response. PMID: 27698401
    3. MERS-CoV S protein binds to DPP4 to suppress macrophage activation via induction of IRAK-M, PPARgamma and the immunosuppressive cytokine IL-10. PMID: 28118607
    4. Data indicate a strong positive correlation between interleukin-1 receptor-associated kinase 3 (IRAK-M) and pSTAT3 protein in colorectal cancer (CRC). PMID: 27150039
    5. IRAK-M functions to modulate inflammatory signaling pathways and is critical in maintaining immune system homeostasis in the gut. However, increased IRAK-M is associated with increased disease pathogenesis and increased cancer severity in human patients. PMID: 27939424
    6. Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes PMID: 26309029
    7. IRAK3 methylation was associated with tumor stage and poor prognosis of hepatocellular carcinoma patients. PMID: 25852282
    8. The structure function of the death domain of human IRAK-M PMID: 25481771
    9. HIF1alpha is a regulator of monocyte functional re-programming in sepsis via regulating IRAKM expression. PMID: 25746953
    10. IRAK-M expression is upregulated in peripheral blood cells from idiopathic pulmonary fibrosis patients PMID: 25595781
    11. our study demonstrates that patients carrying IRAK-M+22148 G haplotype are more susceptible to sepsis than patients carrying IRAK-M+22148 A haplotype, suggesting that IRAK-M+22148 G haplotype might be a risk factor for sepsis. PMID: 23588345
    12. These data indicate the enhancing effect of IRAK-M on epithelial human rhinovirus-16 infection, which is partly through the autophagic pathway. PMID: 24074582
    13. IRAK-M mediates TLR7-induced MEKK3-dependent second wave NFjB activation to produce inhibitory molecules PMID: 23376919
    14. the tested variations of IRAK-M and SIGIRR genes do not confer a relevant role in the susceptibility to systemic lupus erythematosus in European-descent populations PMID: 22634523
    15. these data identify an important signaling regulator in human macrophages that is used by surfactant to control the long-term alveolar inflammatory response, i.e., enhanced IRAK-M activity. PMID: 22886503
    16. these data indicate that epithelial IRAK-M overexpression in T(H)2 cytokine-exposed airways inhibits TLR2 signaling, providing a novel mechanism for the increased susceptibility of infections in asthmatic patients. PMID: 22154382
    17. Data suggest further evaluation of IRAK3 as a diagnostic and prognostic marker, and as a target for intervention. PMID: 22272346
    18. The results confirm the importance of the IRAK3 in asthma pathogenesis in the European populations PMID: 22070913
    19. The upregulation of IRAK-M in macrophages is involved in the local immunosuppression around implants, and may contribute to septic and aseptic implant loosening. PMID: 21987497
    20. Common SNPs in the IRAK3 gene may be determinants of sepsis-induced acute lung injury. PMID: 21297081
    21. Data demonstrates that TGF-beta-dependent induction of IRAK-M expression is an important, clinically relevant mechanism by which tumors may circumvent anti-tumor responses of macrophages. PMID: 21278795
    22. Intact IRAK-M is strongly expressed in resting human alveolar macrophages but is cleaved in patients with pneumonia via neutrophil-mediated induction of caspase-6 (CASP-6) activity. PMID: 21098228
    23. Identification and characterization of murine IRAK-M PMID: 12054681
    24. Thus, our data indicate that IRAK-M could play a pivotal role in the process of endotoxin tolerance in human monocytes and provide evidence that PI3K is involved in regulating its expression. PMID: 14592437
    25. IRAK-M is rapidly upregulated in human monocytes pre-exposed to tumor cells and could be involved in deactivation of tumor-infiltrating monocytes mediated by tumor cells. PMID: 15728517
    26. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. PMID: 17379480
    27. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. PMID: 17503328
    28. no evidence to suggest association between inflammatory bowel disease, Crohn's disease (CD), ulcerative colitis (UC) or subsets of CD & UC and IRAK-M; an interaction was found between IRAK-M and CARD15 in UC patients PMID: 17558906
    29. LPS tolerance in human endotoxemia models is associated with IRAK-M up-regulation. PMID: 17982103
    30. Porphyromonas gingivalis lipopolysaccharide upregulates IRAK-M in macrophages. PMID: 18156187
    31. observed striking up-regulation of IRAK-M in monocytes, but without concomitant proinflammatory cytokine production PMID: 18354163
    32. Analysis of single single nucleotide polymorphisms and haplotypes did not reveal a significant association between polymorphisms in the IRAK-M gene and atopic dermatitis in this cohort. PMID: 19013233
    33. Immunosuppression in sepsis caused by B. pseudomallei is associated with an upregulation of IRAK-M and an indicator of poor outcome. PMID: 19114913
    34. IRAK-M is a major mediator of globular adiponectin-induced endotoxin tolerance in primary macrophages PMID: 19414798
    35. Nine SNPs distributed across eight genetic regions (ALOX5, IRAK3, ITGB2, NCF2, NFKB1, SELP, SOD1, and STAT1) were associated with risk of glioma with P value of <0.01. PMID: 19423540
    36. inhibition of LPS-induced NFKB and ERK activation by acute alcohol leads to hyporesponsiveness of monocytes to LPS due to increased IRAK-M; chronic alcohol sensitizes monocytes to LPS through decreased IRAK-M expression and activation of NFKB and ERK PMID: 19561104

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  • 相关疾病：
    Asthma-related traits 5 (ASRT5)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
  • 组织特异性：
    Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 17020

    OMIM: 604459

    KEGG: hsa:11213

    STRING: 9606.ENSP00000261233

    UniGene: Hs.369265