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  4. IPO13 Antibody

IPO13 Antibody

  • 货号：
    CSB-PA011776GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O94829
  • 基因名：
    IPO13
  • 别名：
    Imp 13 antibody; Imp13 antibody; Importin-13 antibody; Importin13 antibody; IPO 13 antibody; Ipo13 antibody; IPO13_HUMAN antibody; Kap 13 antibody; Kap13 antibody; Karyopherin 13 antibody; Karyopherin-13 antibody; Karyopherin13 antibody; KIAA0274 antibody; Late gestation lung 2 antibody; Late gestation lung 2 protein antibody; Lgl2 antibody; Ran binding protein 13 antibody; Ran-binding protein 13 antibody; RanBP 13 antibody; RanBP13 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IPO13
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
  • 基因功能参考文献：
    1. IPO13 influenced intracellular distribution of CTCF. PMID: 23620300
    2. IPO13 may contribute to the pathogenesis of pterygium via modulation of K17 and c-Jun. PMID: 23559854
    3. Imp13 is able to bind and export eIF1A in vivo and that its function is essential. PMID: 23435562
    4. These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma. PMID: 22648251
    5. Data show that expression of IPO13, c-kit, telomerase, caspase3, and CD146 are decreased in endometrial polyps; however, the expression of bcl-2 was increased in polyps compared to the normal endometrial tissue. PMID: 21804459
    6. IPO13 is uniquely expressed by human limbal basal epithelial cells, and plays an important role in maintaining the phenotype, high proliferative potential, and less differentiation of corneal epithelial progenitor cells. PMID: 19593795
    7. Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation. PMID: 17828378
    8. Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers PMID: 19218565
    9. IPO13 variation may improve nuclear bioavailability of endogenous glucocorticoids PMID: 19619331

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin beta family
  • 组织特异性：
    Expressed in fetal brain, heart, intestine and kidney.
  • 数据库链接：

    HGNC: 16853

    OMIM: 610411

    KEGG: hsa:9670

    STRING: 9606.ENSP00000361418

    UniGene: Hs.158497