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INTS6 Antibody

  • 货号：
    CSB-PA011764LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA011764LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) INTS6 Polyclonal antibody
  • Uniprot No.：
    Q9UL03
  • 基因名：
    INTS6
  • 别名：
    DBI 1 antibody; DBI-1 antibody; DBI1 antibody; DDX26 antibody; DDX26A antibody; DEAD box protein antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26 antibody; Deleted in cancer 1 antibody; DICE1 antibody; DKFZp434B105 antibody; HDB antibody; Int6 antibody; INT6_HUMAN antibody; Integrator complex subunit 6 antibody; INTS 6 antibody; ints6 antibody; Notchl2 antibody; OTTHUMP00000018439 antibody; OTTHUMP00000215034 antibody; OTTHUMP00000215036 antibody; Protein DDX26 antibody; Protein deleted in cancer 1 antibody; RNA helicase HDB antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Integrator complex subunit 6 protein (571-795AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，INTS6 Antibody (CSB-PA011764LA01HU)，的标记方式是Non-conjugated。对于INTS6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011764LB01HU INTS6 Antibody, HRP conjugated ELISA
    FITC CSB-PA011764LC01HU INTS6 Antibody, FITC conjugated
    Biotin CSB-PA011764LD01HU INTS6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
  • 基因功能参考文献：
    1. DICE1 appears to be involved in prostate cancer progression rather than in the initiation of prostate cancer. PMID: 25660097
    2. Findings demonstrate INTS6P1 and INTS6 exert the tumor suppressive roles through competing for oncomiR-17-5p. PMID: 25686840
    3. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. PMID: 23986477
    4. Findings suggest that EBV encoded miR-BART3* miRNA targets DICE1 tumor suppressor to promote cellular growth and transformation in nasopharyngeal cancer(NPC). PMID: 23280823
    5. Molecular characterization of the tumor suppressor gene in lung carcinoma cells PMID: 11939413
    6. Somatic mutations were identified in three patients (3/56, 5%), and one novel polymorphism was identified in 3% of ESCC patients (4/136) and 3% of healthy individuals (6/232). We conclude that DICE1 mutations occur in ESCC but are infrequent. PMID: 12527901
    7. DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling PMID: 15254679
    8. Not mutated in human cancer cell lines which demonstratse 13q14 deletions. PMID: 16271964

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Integrator subunit 6 family
  • 组织特异性：
    Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 14879

    OMIM: 604331

    KEGG: hsa:26512

    STRING: 9606.ENSP00000310260

    UniGene: Hs.439440