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  4. INPP5B Antibody

INPP5B Antibody

  • 货号：
    CSB-PA011734GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P32019
  • 基因名：
  • 别名：
    4 antibody; 5-trisphosphate 5-phosphatase antibody; 5PTase antibody; 75 kDa inositol polyphosphate 5 phosphatase antibody; 75 kDa inositol polyphosphate-5-phosphatase antibody; 75kDa antibody; EC 3.1.3.36 antibody; I5P2_HUMAN antibody; Inositol polyphosphate 5-phosphatase II antibody; Inositol polyphosphate-5-phosphatase B antibody; Inositol polyphosphate-5-phosphatase; 75kDa antibody; INPP5B antibody; Inpp5b protein antibody; INPP5P antibody; MGC65156 antibody; MGC71303 antibody; OTTHUMP00000004726 antibody; OTTHUMP00000004727 antibody; OTTHUMP00000004728 antibody; Phosphoinositide 5 phosphatase antibody; Phosphoinositide 5-phosphatase antibody; Type II inositol 1,4,5 trisphosphate 5 phosphatase antibody; Type II inositol-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human INPP5B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
  • 基因功能参考文献：
    1. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells PMID: 25305077
    2. The crystal structures of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. PMID: 24704254
    3. study found mouse Inpp5b and human INPP5B differ in their transcription, splicing and amino acid sequence; observations form foundation for analyzing the functional basis for the difference in how Inpp5b and INPP5B compensate for loss of Ocrl function PMID: 20872266
    4. The homologous phosphatase Inpp5b was unable to complement the Ocrl1-dependent cell migration defect. PMID: 19700499
    5. INPP5B is also localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC). PMID: 17956944
    6. The NH2-terminal region of OCRL, but not of INPP5B, binds clathrin heavy chain. PMID: 19536138

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  • 亚细胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane. Golgi apparatus.
  • 蛋白家族：
    Inositol 1,4,5-trisphosphate 5-phosphatase type II family
  • 组织特异性：
    Platelets.
  • 数据库链接：

    HGNC: 6077

    OMIM: 147264

    KEGG: hsa:3633

    STRING: 9606.ENSP00000362115

    UniGene: Hs.449942