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INPP5A Antibody

  • 货号：
    CSB-PA011733GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14642
  • 基因名：
  • 别名：
    4 antibody; 43 kDa inositol polyphosphate 5-phophatase antibody; 5-trisphosphate 5-phosphatase antibody; 5PTase antibody; CTCL tumor antigen HD-CL-02 antibody; DKFZp434A1721 antibody; I5P1 antibody; I5P1_HUMAN antibody; Inositol polyphosphate 5 phosphatase antibody; inositol polyphosphate-5-phosphatase A antibody; inositol trisphosphate-5-phosphatase antibody; INPP5A antibody; INPP5A inositol polyphosphate-5-phosphatase antibody; InsP3 5-phosphatase antibody; MGC116947 antibody; MGC116949 antibody; Type I inositol-1 antibody; type I inositol-1,4,5-trisphosphate 5-phophatase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human INPP5A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells.
  • 基因功能参考文献：
    1. the overexpression of miR-181a-5p enhanced cell proliferation and invasion and inhibited apoptosis of cervical cancer cells by negatively targeting INPP5A PMID: 28653606
    2. The ataxic phenotype and characteristics neurodegeneration of the Inpp5a Gt(OST50073)Lex mouse indicate a crucial role for Inpp5a in purkinje cells survival. PMID: 26051944
    3. NPP5Amay play a role in development and progression of cutaneous squamous cell carcinoma tumors PMID: 20876729
  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cell projection, dendrite.
  • 蛋白家族：
    Inositol 1,4,5-trisphosphate 5-phosphatase type I family
  • 组织特异性：
    Predominantly expressed in heart, brain, and skeletal muscle. In brain; high level in Purkinje cells.
  • 数据库链接：

    HGNC: 6076

    OMIM: 600106

    KEGG: hsa:3632

    STRING: 9606.ENSP00000357583

    UniGene: Hs.523360