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INF2 Antibody

  • 货号：
    CSB-PA637740LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA637740LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA637740LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) INF2 Polyclonal antibody
  • Uniprot No.：
    Q27J81
  • 基因名：
    INF2
  • 别名：
    C14orf151 antibody; C14orf173 antibody; CMTDIE antibody; DKFZp762A0214 antibody; FLJ22056 antibody; FSGS5 antibody; HBEAG binding protein 2 binding protein C antibody; HBEBP2 binding protein C antibody; HBEBP2-binding protein C antibody; INF 2 antibody; inf2 antibody; INF2_HUMAN antibody; Inverted formin 2 antibody; Inverted formin FH2 and WH2 domain containing antibody; Inverted formin-2 antibody; MGC13251 antibody; pp9484 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Inverted formin-2 protein (926-1047AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，INF2 Antibody (CSB-PA637740LA01HU)，的标记方式是Non-conjugated。对于INF2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA637740LB01HU INF2 Antibody, HRP conjugated ELISA
    FITC CSB-PA637740LC01HU INF2 Antibody, FITC conjugated
    Biotin CSB-PA637740LD01HU INF2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Severs actin filaments and accelerates their polymerization and depolymerization.
  • 基因功能参考文献：
    1. INF2-mediated actin polymerization on the endoplasmic reticulum stimulates mitochondrial division by two independent mechanisms: (1) mitochondrial calcium uptake, leading to inner mitochondrial membrane constriction; and (2) Drp1 oligomerization, leading to outer mitochondrial membrane constriction. PMID: 29142021
    2. Studies indicate that INF2, a formin, that is mutated in hereditary renal and neurodegenerative disorders. PMID: 29947928
    3. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
    4. hese findings reveal novel molecular events underlying the regulation of INF2 function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer. PMID: 28448495
    5. All individuals with INF2 mutations presenting with a thrombotic microangiopathy also had atypical hemolytic uremic syndrome risk haplotypes, potentially accounting for the genetic pleiotropy PMID: 27974406
    6. Propose that examination of INF2 expression may help to differentiate minimal change disease from focal segmental glomerulosclerosis and evaluate the clinical severity of steroid resistance nephrotic syndrome in children. PMID: 26383224
    7. FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes. PMID: 26621033
    8. Report novel mutations in the inverted formin 2 gene of Chinese families contributing to focal segmental glomerulosclerosis. PMID: 26039629
    9. Assembly and turnover of short actin filaments by the formin INF2 and profilin. PMID: 26124273
    10. INF2 mutations are associated with focal segmental glomerulosclerosis. PMID: 25165188
    11. this study identifed three novel mutations of INF likely efect hereditary neuropathy with glomerulopathy. PMID: 24174593
    12. actin monomer binding to the DAD of INF2 competes with the DID/DAD interaction, thereby activating actin polymerization PMID: 23921379
    13. INF2 mutation was detected both father and his son PMID: 23847988
    14. This study showed that INF2 mutations in Charcot-Marie-Tooth disease complicated with focal segmental glomerulosclerosis. PMID: 23521651
    15. In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
    16. INF2 mutations were found in 2 of 281 individuals with sporadicfocal and segmental glomerulosclerosis PMID: 23014460
    17. Our study confirms the link between INF2 mutations and Charcot-Marie-Tooth-associated glomerulopathy and widens the spectrum of pathogenic mutations. PMID: 22961558
    18. A novel mutation, outside of the candidate region for diagnosis, in the inverted formin 2 gene can cause focal segmental glomerulosclerosis. PMID: 22971997
    19. Formation of stabilized, detyrosinated microtubules required the formin INF2. PMID: 22986496
    20. study found actin polymerization through ER-localized INF2 was required for efficient mitochondrial fission; INF2-induced actin filaments may drive initial mitochondrial constriction, which allows Drp1-driven secondary constriction PMID: 23349293
    21. Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing. PMID: 22879592
    22. Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. PMID: 21998196
    23. INF2 mutations were responsible for 16% of all cases of autosomal dominant focal and segmental glomerulosclerosis, with these mutations clustered in exon 4. PMID: 21866090
    24. Actin monomers inhibit microtubule binding/bundling by INF2 PMID: 21998204
    25. INF2 mutations appear to cause many cases of FSGS-associated Charcot-Marie-Tooth neuropathy, showing that INF2 is involved in a disease affecting both the kidney glomerulus and the peripheral nervous system. PMID: 22187985
    26. The effects of disease-causing INF2 mutations suggest an important role for this protein and its interaction with other formins in modulating glomerular podocyte phenotype and function. PMID: 21278336
    27. In conclusion, we described an additional familial case of the autosomal dominant form of focalsegmental glomerulosclerosis associated with INF2 mutations. PMID: 20803156
    28. Six of the seven distinct altered residues localized to an INF2 region that corresponded to a subdomain of the mDia1 diaphanous inhibitory domain reported to co-immunoprecipitate with IQ motif-containing GTPase-activating protein 1 PMID: 21258034
    29. Study identified nine independent nonconservative missense mutations in INF2, which encodes a member of the formin family of actin-regulating proteins. PMID: 20023659

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  • 相关疾病：
    Focal segmental glomerulosclerosis 5 (FSGS5); Charcot-Marie-Tooth disease, dominant, intermediate type, E (CMTDIE)
  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 蛋白家族：
    Formin homology family
  • 组织特异性：
    Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
  • 数据库链接：

    HGNC: 23791

    OMIM: 610982

    KEGG: hsa:64423

    STRING: 9606.ENSP00000376410

    UniGene: Hs.24956