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INA Antibody

  • 中文名称：
    INA兔多克隆抗体
  • 货号：
    CSB-PA992889
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extract from Rat brain and Rat hippocampus Tissue using a-Internexin Antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) INA Polyclonal antibody
  • Uniprot No.：
    Q16352
  • 基因名：
    INA
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence around aa.491~495 (E-T-T-I-S
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks.
  • 基因功能参考文献：
    1. Data suggest GRINL1A (GCOM1)-NMDA receptor-internexin-alpha (INA) interaction pathway may be relevant to neuroprotection. PMID: 29339073
    2. It is a neuronal marker, and has been indicated as an immunohistochemical surrogate of chromosome 1p/19q co-deletion in oligodendroglial tumors. PMID: 26233522
    3. Gonadotropinomas, null cell pituitary adenomas, and thyrotropinomas exhibit high levels of intracellular INA protein indicating neuronal transdifferentiation. PMID: 25236435
    4. It is a supportive diagnostic marker for oligodendroglial tumors with the 1p/19q co-deletion. PMID: 24197863
    5. alpha-Internexin was expressed in 53% of 350 pancreatic neuroendocrine tumors. Reduced expression of alpha-internexin was significantly associated with advanced stage metastases, recurrence and shorter overall survival. PMID: 24483152
    6. High INA expression is associated with grade II gliomas. PMID: 22890969
    7. INA may provide additional biologic information relevant to delineation of both pancreatic neuroendocrine neoplasms (NEN) tumor phenotypes and clinical behavior. PMID: 21990041
    8. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
    9. alpha-internexin expression in neuroblastoma PMID: 12209604
    10. The discovery of alpha-internexin in the cytoplasmic inclusions implicates novel mechanisms of pathogenesis in inclusion diseeae and other neurological diseases with pathological accumulations of IFs. PMID: 15161649
    11. Abnormal neuronal intermediate filament inclusions of alpha-internexin have been identified as the pathological hallmark of neuronal intermediate filament inclusion disease PMID: 16722980
    12. Expression of the 2 markers, alpha-internexin and peripherin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma. PMID: 18528283
    13. Alpha-Internexin (INA) expression appears to be a simple, reliable prognostic marker and a surrogate marker of 1p19q codeletion. PMID: 19139367

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  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Found predominantly in adult CNS.
  • 数据库链接：

    HGNC: 6057

    OMIM: 605338

    KEGG: hsa:9118

    STRING: 9606.ENSP00000358865

    UniGene: Hs.500916