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IMPA1 Antibody

  • 货号：
    CSB-PA011694GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P29218
  • 基因名：
  • 别名：
    IMP 1 antibody; IMP antibody; IMPA 1 antibody; IMPA antibody; IMPA1 antibody; IMPA1_HUMAN antibody; IMPase 1 antibody; IMPase antibody; Inositol 1(or 4) monophosphatase antibody; Inositol monophosphatase 1 antibody; Inositol monophosphatase antibody; Inositol(myo) 1(or 4) monophosphatase 1 antibody; Inositol-1(or 4)-monophosphatase 1 antibody; Lithium sensitive myo inositol monophosphatase A1 antibody; Lithium-sensitive myo-inositol monophosphatase A1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IMPA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
  • 基因功能参考文献：
    1. Multibody magnesium cofactor and myo-inositol substrate molecular recognition in the myo-inositol monophosphatase enzyme have been described. PMID: 27440438
    2. The identification of a novel homozygous duplication of 5 bp in IMPA1, in a large consanguineous family with nine individuals with severe intellectual disability and disruptive behavior. PMID: 26416544
    3. Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A PMID: 23027737
    4. The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis. PMID: 20153384
    5. No association between polymorphisms and bipolar disorder PMID: 14699425
    6. IMPA2 has a separate function in vivo from that of IMPA1 PMID: 17068342

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  • 相关疾病：
    Mental retardation, autosomal recessive 59 (MRT59)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Inositol monophosphatase superfamily
  • 数据库链接：

    HGNC: 6050

    OMIM: 602064

    KEGG: hsa:3612

    STRING: 9606.ENSP00000408526

    UniGene: Hs.656694