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IMP3 Antibody

  • 货号：
    CSB-PA290241
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HEPG2 cells using Antibody diluted at 1000. Secondary antibody was diluted at 1:20000
    • Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q9NV31
  • 基因名：
    IMP3
  • 别名：
    BRMS2 antibody; C15orf12 antibody; Chromosome 15 open reading frame 12 antibody; DKFZp586L0118 antibody; FLJ10968 antibody; imp3 antibody; IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) antibody; IMP3_HUMAN antibody; Mitochondrial ribosomal protein S4 antibody; MRPS4 antibody; OTTHUMP00000183524 antibody; U3 small nucleolar ribonucleoprotein protein imp3 antibody; U3 snoRNP protein 3 homolog antibody; U3 snoRNP protein imp3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 135-184
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-10000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
  • 基因功能参考文献：
    1. our study found that IMP3 expression was higher in the ovarian clear cell carcinoma than the high grade serous and endometrioid subtypes PMID: 29866423
    2. IMP3 expression in uterine leiomyosarcoma could be a marker of a poor prognosis. PMID: 29077232
    3. IMP3 positive pT1 EAC revealed higher levels of lymph node metastases. PMID: 29974234
    4. IMP3 is a strong prognostic factor in non-neuroendocrine brain metastases and in particular in patients with adenocarcinoma metastases.IMP3 expression is associated with poor prognosis in patients with non-small cell lung cancer brain metastases. PMID: 29209838
    5. Study found IMP3 frequently overexpressed in many human neoplasms and show significant associations with adverse tumor features in esophageal adenocarcinomas and cancers of the urinary bladder, lung, stomach, and pancreas. PMID: 29115542
    6. In this study, IMP3 at the nodal site resulted to be associated with low progression-free survival in small-intestine neuroendocrine neoplasms, independently of the Ki-67 index. PMID: 28210937
    7. IMP3 may contribute to the aggressive behavior of metaplastic breast carcinoma , and that this expression could potentially be a prognostic marker PMID: 29146055
    8. These findings suggest that IMP3 expression has prognostic value as a biomarker for chemosensitivity and overall survival in triple negative breast cancer PMID: 28756977
    9. This study establishes p65 as a novel target of IMP3 in increasing glioma cell migration and underscores the significance of IMP3-p65 feedback loop for therapeutic targeting in GBM. PMID: 28465487
    10. IMP3 has a similar specificity, but a better sensitivity, intensity, and extent of reactivity in comparison with AMACR, and may be used as an alternative to AMACR, in support of the diagnosis of BE-dysplasia and EAC PMID: 26766126

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  • 亚细胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Universal ribosomal protein uS4 family
  • 数据库链接：

    HGNC: 14497

    OMIM: 612980

    KEGG: hsa:55272

    STRING: 9606.ENSP00000326981

    UniGene: Hs.513043