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ILKAP Antibody

  • 货号：
    CSB-PA011686HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ILKAP antibody at 2µg/ml
      Lane 1: Rat kidney tissue
      Lane 2: U251 whole cell lysate
      Lane 3: Mouse stomach tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ILKAP Polyclonal antibody
  • Uniprot No.：
    Q9H0C8
  • 基因名：
    ILKAP
  • 别名：
    DKFZp434J2031 antibody; FLJ10181 antibody; ILKAP antibody; ILKAP_HUMAN antibody; ILKAP2 antibody; ILKAP3 antibody; Integrin linked kinase associated phosphatase antibody; Integrin linked kinase associated serine/threonine phosphatase 2C antibody; Integrin linked kinase associated serine/threonine phosphatase antibody; Integrin-linked kinase-associated serine/threonine phosphatase 2C antibody; MGC4846 antibody; PP2C DELTA antibody; Protein phosphatase 2c delta isozyme antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Integrin-linked kinase-associated serine/threonine phosphatase 2C protein (1-392AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ILKAP Antibody (CSB-PA011686HA01HU)，的标记方式是Non-conjugated。对于ILKAP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011686HB01HU ILKAP Antibody, HRP conjugated ELISA
    FITC CSB-PA011686HC01HU ILKAP Antibody, FITC conjugated
    Biotin CSB-PA011686HD01HU ILKAP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
  • 基因功能参考文献：
    1. ILKAP physically interacted with HIF-1A and induced its dephosphorylation. Both the HIF-1A-p53 interaction and apoptosis relied on ILKAP. PMID: 29742494
    2. our data suggest an essential role of PINCH1, ILK and ILKAP for the radioresistance of p53-wildtype glioblastoma multiforme cells PMID: 26460618
    3. The expression of ILKAP was considerably lower in eutopic and ectopic endometrial samples from women with endometriosis than in control endometrium. Expression varied depending on the phase of the menstrual cycle. PMID: 25872452
    4. Data show involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma PMID: 24743186
    5. ILKAP is a nuclear protein that regulates cell survival and apoptosis through the regulation of RSK2 signaling. PMID: 23329845
    6. these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis. PMID: 21782789

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    PP2C family
  • 组织特异性：
    Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
  • 数据库链接：

    HGNC: 15566

    KEGG: hsa:80895

    STRING: 9606.ENSP00000254654

    UniGene: Hs.92033