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IL22RA2 Antibody

  • 货号：
    CSB-PA850247ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA850247ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA850247ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IL22RA2 Polyclonal antibody
  • Uniprot No.：
    Q969J5
  • 基因名：
  • 别名：
    IL 22BP antibody; IL 22RA2 antibody; IL22RA2 antibody; Class II cytokine receptor antibody; CRF2 10 antibody; CRF2 S1 antibody; CRF2-10 antibody; CRF2-S1 antibody; CRF2X antibody; Cytokine receptor class II member 10 antibody; Cytokine receptor class-II member 10 antibody; Cytokine receptor family 2 member 10 antibody; Cytokine receptor family type 2 antibody; Cytokine receptor family type 2 soluble 1 antibody; I22R2_HUMAN antibody; IL 22 receptor subunit alpha 2 antibody; IL 22R alpha 2 antibody; IL-22 receptor subunit alpha-2 antibody; IL-22BP antibody; IL-22R-alpha-2 antibody; IL-22RA2 antibody; IL22 RA2 antibody; IL22BP antibody; IL22R alpha 2 antibody; Il22ra2 antibody; Interleukin 22 binding protein antibody; Interleukin 22 Receptor alpha 2 antibody; Interleukin-22 receptor subunit alpha-2 antibody; Interleukin-22-binding protein antibody; MGC150509 antibody; MGC150510 antibody; soluble 1 antibody; ZcytoR16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Interleukin-22 receptor subunit alpha-2 protein (22-231AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; Isoform 1 may play a role in establishing and maintaining successful pregnancy.
  • 基因功能参考文献：
    1. expression higher in the epidermal compartment of the skin in comparison with dermis in both healthy skin and psoriasis skin PMID: 27676439
    2. suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. PMID: 27678220
    3. thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP PMID: 28356382
    4. The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription. PMID: 26931784
    5. IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID: 26329427
    6. Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID: 21041731
    7. The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID: 18675824
    8. Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 binding protein (IL-22BP) complex are described. PMID: 19193995
    9. Polymorphisms in IL22RA1 are associated with severe CRS. PMID: 19393422

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 组织特异性：
    Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placen
  • 数据库链接：

    HGNC: 14901

    OMIM: 606648

    KEGG: hsa:116379

    STRING: 9606.ENSP00000296980

    UniGene: Hs.126891