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IL20RA Antibody

  • 货号：
    CSB-PA003025
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of LOVO cells using IL-20Rα Polyclonal Antibody
    • Western Blot analysis of Jurkat cells using IL-20Rα Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHF4
  • 基因名：
  • 别名：
    class II cytokine receptor ZCYTOR7 antibody; CRF2 8 antibody; CRF2-8 antibody; Cytokine receptor class II member 8 antibody; Cytokine receptor class-II member 8 antibody; Cytokine receptor family 2 member 8 antibody; I20RA_HUMAN antibody; IL 20R alpha antibody; IL 20R1 antibody; IL-20 receptor subunit alpha antibody; IL-20R-alpha antibody; IL-20R1 antibody; IL-20RA antibody; IL20 Receptor alpha antibody; IL20RA antibody; Interleukin 20 receptor alpha chain antibody; Interleukin 20 receptor, alpha antibody; interleukin-20 receptor I antibody; Interleukin-20 receptor subunit alpha antibody; ZcytoR7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IL-20Rα.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
  • 基因功能参考文献：
    1. the DNA fragment containing the associated SNPs interacts through chromatin looping not only with TNFAIP3, but also with IL20RA, located 680 kb upstream. PMID: 27799070
    2. IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy. PMID: 26977011
    3. crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54% PMID: 22232181
    4. IL-20RA polymorphisms may have a role in psoriasis PMID: 19926456
    5. Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines. PMID: 19666410
    6. forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2] PMID: 14580208
    7. sensitivity to recombinant interleukin-26(IL-26) of various cell lines strictly correlated with the expression of IL-20 1 receptor and blocking antibodies against either IL-10 receptor 2 or IL-20 receptor 1 inhibited IL-26-dependent signal transduction PMID: 15178681
    8. The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis was investigated. PMID: 18480827

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type II cytokine receptor family
  • 组织特异性：
    Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.
  • 数据库链接：

    HGNC: 6003

    OMIM: 605620

    KEGG: hsa:53832

    STRING: 9606.ENSP00000314976

    UniGene: Hs.445868