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IL1RAPL1 Antibody

  • 货号：
    CSB-PA011624LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, SH-SY5Y whole cell lysate, U87 whole cell lysate
      All lanes: IL1RAPL1 antibody at 5.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 80 kDa
      Observed band size: 80 kDa
    • IHC image of CSB-PA011624LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA011624LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IL1RAPL1 Polyclonal antibody
  • Uniprot No.：
    Q9NZN1
  • 基因名：
    IL1RAPL1
  • 别名：
    IL 1 RAPL 1 antibody; IL 1RAPL 1 antibody; IL-1-RAPL-1 antibody; IL-1RAPL-1 antibody; IL1R8 antibody; IL1RAPL 1 antibody; IL1RAPL antibody; IL1RAPL-1 antibody; IL1RAPL1 antibody; Interleukin 1 receptor 8 antibody; Interleukin 1 receptor accessory protein like 1 antibody; Interleukin-1 receptor accessory protein-like 1 antibody; IRPL1_HUMAN antibody; Mental retardation X linked 10 antibody; Mental retardation X linked 21 antibody; Mental retardation X linked 34 antibody; MRX 21 antibody; MRX 34 antibody; MRX10 antibody; MRX21 antibody; MRX34 antibody; Oligophrenin 4 antibody; Oligophrenin-4 antibody; Oligophrenin4 antibody; OPHN 4 antibody; OPHN4 antibody; Three immunoglobulin domain containing IL 1 receptor related 2 antibody; Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody; TIGIRR 2 antibody; TIGIRR-2 antibody; TIGIRR2 antibody; X linked interleukin 1 receptor accessory protein like 1 antibody; X-linked interleukin-1 receptor accessory protein-like 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Interleukin-1 receptor accessory protein-like 1 protein (564-679AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IL1RAPL1 Antibody (CSB-PA011624LA01HU)，的标记方式是Non-conjugated。对于IL1RAPL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011624LB01HU IL1RAPL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA011624LC01HU IL1RAPL1 Antibody, FITC conjugated
    Biotin CSB-PA011624LD01HU IL1RAPL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
  • 基因功能参考文献：
    1. Our study revealed that the expression of IL-1R8 significantly increased on in vitro-activated CD4+ T cells and was markedly higher on CD4+ T cells from allergic rhinitis patients than on cells from healthy controls. PMID: 29730558
    2. IL-1R8 serves as a checkpoint for NK cell maturation and effector function; its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection in mice PMID: 29072292
    3. Altered DNA methylation in IL1RAPL1 involves in the etiology of Bipolar disorder and Major Depressive disorder . PMID: 27440233
    4. rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in Latin American children. PMID: 28120837
    5. Our study expands the molecular repertoire of IL1RAPL1 mutations in intellectual disability and points out the need of more accurate clinical descriptions to better define the related phenotype PMID: 27470653
    6. It was indicated that a defect in IL1RAPL1 that controls excitatory synapsis formation results in the excitation-inhibition balance affecting various cerebral functions. PMID: 25864829
    7. Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis. PMID: 25305082
    8. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
    9. The IL1RAPL1 gene is of interest as a candidate gene for autism spectrum disorder as mutations or deletions in the gene have previously been reported in individuals from families with ASD. PMID: 21491612
    10. Intragenic deletions in IL1RAPL1are relevant to the pathogenesis of X-linked mental retardation. PMID: 21271657
    11. crystal structure at 2.3-A resolution of the TIR domain of IL-1RAPL PMID: 15123616
    12. Nearly all patients with deletions involving DAX1, but not DMD, had mental retardation if IL1RAPL1 was deleted. If ILIRAPLI & DMD were intact, the patients with DAX1 deletions only rarely had normal development. PMID: 15300857
    13. Report confirms the role of the IL1RAPL1 gene in causing nonspecific mental retardation in males. PMID: 16470793
    14. DMD gene and its immediately distal neighbor, the 1.8 Mb IL1RAPL1 gene are abundantly expressed in normal brain but were dramatically underexpressed in every brain tumor cell line and xenograft. PMID: 18253029
    15. Combined data suggested that IL1RAPL1 affected human cognitive ability to some extent, especially the memory and concentration capability. PMID: 18467032
    16. The function of truncated IL1RAPL1 protein in an autistic female with Asperger syndrome is severely altered in hippocampal neurons, demonstrated by its effect on neurite outgrowth activity. PMID: 18801879
    17. IL1RAPL1 plays an important role in the etiology of X-linked mental retardation. PMID: 19012350

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  • 相关疾病：
    Mental retardation, X-linked 21 (MRX21)
  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon. Cell projection, dendrite.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 组织特异性：
    Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal live
  • 数据库链接：

    HGNC: 5996

    OMIM: 300143

    KEGG: hsa:11141

    STRING: 9606.ENSP00000305200

    UniGene: Hs.658912