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IGSF8 Antibody

  • 货号：
    CSB-PA005881
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of NIH-3T3 cells using CD316 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q969P0
  • 基因名：
  • 别名：
    CD316 antibody; CD316 antigen antibody; CD81 partner 3 antibody; CD81P3 antibody; EWI-2 antibody; EWI2 antibody; Glu-Trp-Ile EWI motif-containing protein 2 antibody; igsf-8 antibody; IgSF8 antibody; IGSF8_HUMAN antibody; Immunoglobulin superfamily member 8 antibody; Immunoglobulin superfamily member 8 precursor antibody; KCT-4 antibody; KCT4 antibody; Keratinocytes-associated transmembrane protein 4 antibody; LIR-D1 antibody; PGRL antibody; Prostaglandin regulatory-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD316.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
  • 基因功能参考文献：
    1. EWI-2 negatively regulates TGF-beta signaling and its downstream events including cytostasis (in vitro and in vivo), EMT-like changes, cell migration, CD271-dependent invasion, and lung metastasis (in vivo). PMID: 25656846
    2. s demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. PMID: 23351194
    3. The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition. PMID: 22689882
    4. analysis of interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection PMID: 21343309
    5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. PMID: 12750295
    6. EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions PMID: 15070678
    7. EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization PMID: 16537545
    8. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins PMID: 16690612
    9. Important functions of recently activated dendritic cells are thus critically modulated by the newly discovered HSPA8-EWI-2 interaction. PMID: 17785435
    10. CD81 partner EWI-2wint inhibits hepatitis C virus entry [EWI-2wint] PMID: 18382656
    11. EWI-2 causes a substantial molecular reorganization of multiple molecules known to affect proliferation and/or invasion of astrocytes and/or glioblastomas. PMID: 19107234

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  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein.
  • 组织特异性：
    Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
  • 数据库链接：

    HGNC: 17813

    OMIM: 606644

    KEGG: hsa:93185

    STRING: 9606.ENSP00000316664

    UniGene: Hs.332012