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IGBP1 Antibody

  • 货号：
    CSB-PA011082GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P78318
  • 基因名：
  • 别名：
    Alpha 4 antibody; B cell signal transduction molecule alpha 4 antibody; B-cell signal transduction molecule alpha 4 antibody; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ) antibody; bA351K23.1 antibody; CD79a binding protein 1 antibody; CD79a-binding protein 1 antibody; IBP 1 antibody; IBP1 antibody; IGBP 1 antibody; Igbp1 antibody; IGBP1_HUMAN antibody; Immunoglobulin (CD79A) binding protein 1 antibody; Immunoglobulin binding protein 1 antibody; Immunoglobulin-binding protein 1 antibody; Protein alpha 4 antibody; Protein alpha-4 antibody; Protein phosphatase 2/4/6 regulatory subunit antibody; Protein phosphatase 2A regulatory subunit alpha 4 antibody; Renal carcinoma antigen NY REN 16 antibody; Renal carcinoma antigen NY-REN-16 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IGBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
  • 基因功能参考文献：
    1. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac. PMID: 27169767
    2. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
    3. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome. PMID: 25207814
    4. alpha4 is an important regulatory molecule of apoptosis and Bcl-xL phosphorylation induced by BCR crosslinking. PMID: 25876659
    5. the alpha4 N-terminus binding to endogenous PP2Ac and PABP, and the C-terminus to EDD, is reported. PMID: 24145130
    6. A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin expression in bladder urothelial carcinoma. PMID: 24388773
    7. The structure of alpha45 reveals two distinct surfaces, one that can interact with a negatively charged surface, which is present on PP2A, and one that interacts with the Bbox1 domain of MID1. PMID: 22194938
    8. alpha4 is highly expressed in carcinogen-transformed human cells and primary human cancers. PMID: 21339737
    9. both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation. PMID: 21454489
    10. IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome. PMID: 21355954
    11. Data show that in addition to PP2Ac, alpha4 interacts with EDD and PABP, suggesting its involvement in multiple steps in the mTOR pathway that leads to translation initiation and cell-cycle progression. PMID: 20544796
    12. Alpha 4, a regulatory subunit of PP2-type phosphatases and a key component of the rapamycin-sensitive signaling pathway, has been indentified as a strong interactor of both MID1 and MID2. PMID: 11806752
    13. alpha4 C-terminal deletion mutants at 222 (alpha4Delta222), 236 (alpha4Delta236) & 254 (alpha4Delta254) were expressed. alpha4Delta222 & alpha4Delta236 possess a higher content of alpha-helix, indicating that C-terminal region is less structured. PMID: 16517231
    14. a new role for mTOR and alpha4/PP2Ac in the control of STAT1 nuclear content, and the expression of interferon-gamma-sensitive genes involved in immunity and apoptosis. PMID: 19553685

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  • 相关疾病：
    Mental retardation, X-linked, syndromic, 28 (MRXS28)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    IGBP1/TAP42 family
  • 组织特异性：
    Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 5461

    OMIM: 300139

    KEGG: hsa:3476

    STRING: 9606.ENSP00000348784

    UniGene: Hs.496267