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  4. IFT88 Antibody

IFT88 Antibody

  • 货号：
    CSB-PA011080GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q13099
  • 基因名：
    IFT88
  • 别名：
    D13S1056E antibody; DAF19 antibody; hTg737 antibody; Ift88 antibody; IFT88_HUMAN antibody; Intraflagellar transport 88 homolog antibody; Intraflagellar transport protein 88 homolog antibody; MGC26259 antibody; Polaris homolog antibody; Probe hTg737 (polycystic kidney disease; autosomal recessive) antibody; Recessive polycystic kidney disease protein Tg737 homolog antibody; RP11-172H24.2 antibody; Tetratricopeptide repeat domain 10 antibody; Tetratricopeptide repeat protein 10 antibody; TG737 antibody; TPR repeat protein 10 antibody; TTC10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IFT88
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF,IP
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
  • 基因功能参考文献：
    1. BFGF also upregulated the mRNA and protein expression of IFT88 in primary cultured chondrocytes. PMID: 28901443
    2. Data suggest that the function of the fusion transcript crystallin, lambda 1 protein - intraflagellar transport 88 (CRYL1-IFT88) is closed to CRYL1 because it contained most of domain of CRYL1. PMID: 28489570
    3. multivariate Cox regression analyses demonstrated that Tg737 expression was an independent factor for predicting the overall survival of hepatocellular carcinoma patients PMID: 28663060
    4. MiR-548a-5p negatively regulates the tumor inhibitor gene Tg737 and promotes tumorigenesis in vitro and in vivo, indicating its potential as a novel therapeutic target for hepatocellular carcinoma. PMID: 27340352
    5. subtle regulation of IFT and associated cilia structure, tunes the wnt response controlling stem cell differentiation. PMID: 24346024
    6. this work suggests that Tg737 is involved in the invasion and migration of hepatoma cells under hypoxia, with the involvement of the polycystin-1, IL-8, and TGF-beta1 signaling pathway PMID: 22974282
    7. A mutation in IFT88 causes a hitherto unknown human ciliopathy. PMID: 22941275
    8. Data show that IFT88 depletion induces mitotic defects in human cultured cells, in kidney cells from the IFT88 mouse mutant Tg737(orpk) and in zebrafish embryos. PMID: 21441926
    9. The results indicate that loss of heterozygosity of the tumor suppressor gene Tg737 may play an important role in the carcinogenetic mechanism of liver cancer stem cells. PMID: 20300861
    10. IFT88 is a centrosomal protein regulating G1-S transition in non-ciliated cells. PMID: 17264151

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium, flagellum.
  • 组织特异性：
    Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 20606

    OMIM: 600595

    KEGG: hsa:8100

    STRING: 9606.ENSP00000323580

    UniGene: Hs.187376