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IFT81 Antibody

  • 中文名称：
    IFT81兔多克隆抗体
  • 货号：
    CSB-PA011079GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WYA0
  • 基因名：
    IFT81
  • 别名：
    Carnitine deficiency associated expressed in ventricle 1 isoform 2 antibody; Carnitine deficiency-associated protein expressed in ventricle 1 antibody; CDV-1 antibody; CDV1 antibody; CDV1R antibody; Ift81 antibody; IFT81_HUMAN antibody; intraflagellar transport 81 homolog (Chlamydomonas) antibody; Intraflagellar transport protein 81 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human IFT81
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling.
  • 基因功能参考文献：
    1. This represents the first report of mutations in IFT81 as a candidate gene for nonsyndromic retinal dystrophy, hence expanding the phenotype spectrum of IFT-B components. PMID: 28460050
    2. this study found that the two core intraflagellar transport proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. PMID: 23990561
    3. inconsistent expression levels of human CDV-1 and mouse Cdv-1 in heart implied that cardiac hypertrophy in human SCD might not be associated with the abnormal expression of CDV-1 PMID: 12549821
  • 亚细胞定位：
    Cell projection, cilium.
  • 蛋白家族：
    IFT81 family
  • 组织特异性：
    Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis.
  • 数据库链接：

    HGNC: 14313

    OMIM: 605489

    KEGG: hsa:28981

    STRING: 9606.ENSP00000242591

    UniGene: Hs.528382