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IFT74 Antibody

  • 货号：
    CSB-PA846657LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA846657LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IFT74 Polyclonal antibody
  • Uniprot No.：
    Q96LB3
  • 基因名：
    IFT74
  • 别名：
    intraflagellar transport 74, Chlamydomonas, homolog of antibody; Capillary morphogenesis gene 1 protein antibody; Capillary morphogenesis protein 1 antibody; Ccdc2 antibody; CMG 1 antibody; CMG-1 antibody; Coiled-coil domain containing 2 antibody; Coiled-coil domain-containing protein 2 antibody; IFT74 antibody; IFT74_HUMAN antibody; intraflagellar transport 74 homolog (Chlamydomonas) antibody; intraflagellar transport 74 homolog antibody; Intraflagellar transport protein 74 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Intraflagellar transport protein 74 homolog protein (375-600AA )
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IFT74 Antibody (CSB-PA846657LA01HU)，的标记方式是Non-conjugated。对于IFT74 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA846657LB01HU IFT74 Antibody, HRP conjugated ELISA
    FITC CSB-PA846657LC01HU IFT74 Antibody, FITC conjugated
    Biotin CSB-PA846657LD01HU IFT74 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.
  • 基因功能参考文献：
    1. this study found that the two core intraflagellar transport proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. PMID: 23990561
    2. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. PMID: 17383054
  • 相关疾病：
    Bardet-Biedl syndrome 20 (BBS20)
  • 亚细胞定位：
    Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.
  • 蛋白家族：
    IFT74 family
  • 组织特异性：
    Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thym
  • 数据库链接：

    HGNC: 21424

    OMIM: 608040

    KEGG: hsa:80173

    STRING: 9606.ENSP00000369402

    UniGene: Hs.145402