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IFITM5 Antibody

  • 货号：
    CSB-PA011028HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA011028HA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA011028HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) IFITM5 Polyclonal antibody
  • Uniprot No.：
    A6NNB3
  • 基因名：
    IFITM5
  • 别名：
    IFITM5; Interferon-induced transmembrane protein 5; Bone-restricted interferon-induced transmembrane protein-like protein; BRIL; Dispanin subfamily A member 1; DSPA1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Interferon-induced transmembrane protein 5 protein (1-36AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，IFITM5 Antibody (CSB-PA011028HA01HU)，的标记方式是Non-conjugated。对于IFITM5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA011028HB01HU IFITM5 Antibody, HRP conjugated ELISA
    FITC CSB-PA011028HC01HU IFITM5 Antibody, FITC conjugated
    Biotin CSB-PA011028HD01HU IFITM5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for normal bone mineralization.
  • 基因功能参考文献：
    1. Two mutations in IFITM5 causing distinct forms of osteogenesis imperfect. PMID: 24478195
    2. The point mutation, c.-14C>T in the 5'-untranslated region of IFITM5, is responsible for osteogenesis imperfecta type V in Chinese patients. PMID: 23977282
    3. The IFITM5 5' UTR was sequenced in 9 heterozygous subjects with osteogenesis imperfecta type V. Both wild-type and mutant IFITM5 mRNA transcripts were present in bone. Identical mutations have variable phenotypic expression, even within the same family. PMID: 24674092
    4. The bone mineral density varied greatly, even within families. Our study thus highlights the phenotypic variability of OI type V caused by the IFITM5 mutation. PMID: 23408678
    5. Recurrent mutation in the 5'-UTR of IFITM5 causes osteogenesis imperfecta type V. PMID: 23813632
    6. IFITM5 mutation is associated with Osteogenesis imperfecta type V. PMID: 23804581
    7. study demonstrates the presence of a recurrent IFITM5 mutation in a population of patients with osteogenesis imperfecta type V; even though the disease-causing mutation is identical among patients, the interindividual phenotypic variability is considerable PMID: 23240094
    8. A single recurrent mutation in the 5'-UTR of IFITM5 causes osteogenesis imperfecta type V. PMID: 22863190
    9. A mutation in the 5'-UTR of IFITM5 creates an in-frame start codon and causes autosomal-dominant osteogenesis imperfecta type V with hyperplastic callus. PMID: 22863195

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  • 相关疾病：
    Osteogenesis imperfecta 5 (OI5)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CD225/Dispanin family
  • 组织特异性：
    Detected in bone. Detected in osteoblasts and fibroblasts (at protein level). Detected in bone. Detected in osteoblasts and fibroblasts.
  • 数据库链接：

    HGNC: 16644

    OMIM: 610967

    KEGG: hsa:387733

    STRING: 9606.ENSP00000372059

    UniGene: Hs.443469