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IDH3G Antibody

  • 货号：
    CSB-PA952993
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA952993(IDH3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA952993(IDH3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, NIH/3T3 cells, Primary antibody: CSB-PA952993(IDH3G Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P51553
  • 基因名：
    IDH3G
  • 别名：
    H IDHG antibody; IDH gamma antibody; IDH3G antibody; IDH3G_HUMAN antibody; Isocitrate dehydrogenase [NAD] subunit gamma antibody; Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial antibody; Isocitrate dehydrogenase 3 (NAD+) gamma antibody; Isocitric dehydrogenase antibody; Isocitric dehydrogenase subunit gamma antibody; mitochondrial antibody; NAD (H) specific isocitrate dehydrogenase gamma subunit antibody; NAD(+) specific ICDH antibody; NAD(+)-specific ICDH subunit gamma antibody; NAD+ specific ICDH antibody; OTTHUMP00000025984 antibody; OTTHUMP00000025985 antibody; OTTHUMP00000025987 antibody; OTTHUMP00000025988 antibody; OTTHUMP00000214764 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human IDH3G
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
  • 基因功能参考文献：
    1. Aspartate-190 is a determinant of IDH gamma subunit affinity for the manganese (MnII) ion, as well as for nicotinamide-adenine dinucleotide (NAD), but is not directly required for the catalytic reaction. PMID: 17432878
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Isocitrate and isopropylmalate dehydrogenases family
  • 数据库链接：

    HGNC: 5386

    OMIM: 300089

    KEGG: hsa:3421

    STRING: 9606.ENSP00000217901

    UniGene: Hs.410197